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Non-standard amino acids (nsAAs) that are L-phenylalanine derivatives with aryl ring functionalization have long been harnessed in natural product synthesis, therapeutic peptide synthesis, and diverse applications of genetic code expansion. Yet, to date these chiral molecules have often been the products of poorly enantioselective and environmentally harsh organic synthesis routes. Here, we reveal the broad specificity of multiple natural pyridoxal 5'-phosphate (PLP)-dependent enzymes, specifically an L-threonine transaldolase, a phenylserine dehydratase, and an aminotransferase, towards substrates that contain aryl side chains with diverse substitutions.
View Article and Find Full Text PDFA Stable Dehydratase Complex Catalyzes the Formation of Dehydrated Amino Acids in a Class V Lanthipeptide.
ACS Chem Biol
December 2024
School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides that bear the characteristic lanthionine (Lan) or methyllanthionine (MeLan) thioether linkages. (Me)Lan moieties bestow lanthipeptides with robust stability and diverse antimicrobial, anticancer, and antiallodynic activities. Installation of (Me)Lan requires dehydration of serine and threonine residues to 2,3-dehydroalanine (Dha) and ()-2,3-dehydrobutyrine (Dhb), respectively.
View Article and Find Full Text PDFTargeting threonine deaminase with chiral Au NPs: A novel strategy for E. coli inhibition.
Biochem Biophys Res Commun
December 2024
College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China; Key Laboratory of Food Contact Materials Safety, State Administration for Market Regulation, China. Electronic address:
Bacterial infections are becoming a significant threat to global human health due to the growing prevalence of biofilm-related infections and the rise in antibiotic resistance. D/l-cysteine functionalized chiral gold nanoparticles (D/P-Au NPs or L/P-Au NPs) have demonstrated a potent antibacterial effect against E. coli, while the mechanism remains to be elucidated through additional research.
View Article and Find Full Text PDFThe Microbial Metabolite Wuyiencin Potential Targets Threonine dehydratase in to Achieve Control of Tea Leaf Spot.
Phytopathology
October 2024
Guizhou University, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Huaxi District, Guiyang, Guizhou Province of China, Guiyang, China, 550025;
Tea leaf spot caused by is a disease that has recently been discovered in the tea plantations of Southwest China, and which has a significant negative impact on the yield and quality of tea leaves. Wuyiencin is a nucleotide antimicrobial that is effective against a range of fungal diseases. However, its mode of action is still unclear.
View Article and Find Full Text PDFRidA proteins contribute to fitness of and by reducing 2AA stress and moderating flux to isoleucine biosynthesis.
Microb Cell
October 2024
Department of Microbiology, University of Georgia Athens, GA 30602-2605.
Defining the physiological role of a gene product relies on interpreting phenotypes caused by the lack, or alteration, of the respective gene product. Mutations in critical genes often lead to easily recognized phenotypes that can include changes in cellular growth, metabolism, structure etc. However, mutations in many important genes may fail to generate an obvious defect unless additional perturbations are caused by medium or genetic background.
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