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Simultaneous site-directed mutagenesis for soybean ß-amyrin synthase genes via DNA-free CRISPR/Cas9 system using a single gRNA.
Plant Cell Rep
January 2025
Graduate School of Agriculture, Hokkaido University, Kita 9, Nishi 9, Kita-ku, Sapporo, Hokkaido, 060-8589, Japan.
We generated soybean mutants related to two ß-amyrin synthase genes using DNA-free site-directed mutagenesis system. Our results suggested that one of the genes is predominant in the soyasaponin biosynthesis. Soyasaponins, which are triterpenoid saponins contained in soybean [Glycine max (L.
View Article and Find Full Text PDFResearch progress on the molecular mechanisms of Saikosaponin D in various diseases (Review).
Int J Mol Med
March 2025
Department of Gastroenterology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China.
Bupleurum, a Traditional Chinese Medicine (TCM) herb, is widely used in China and other Asian countries to manage chronic liver inflammation and viral hepatitis. Saikosaponin D (SSD), a triterpenoid saponin extracted from Bupleurum, exhibits extensive pharmacological properties, including anti‑inflammatory, antioxidant, anti‑apoptotic, anti‑fibrotic and anti‑cancer effects, making it a therapeutic candidate for numerous diseases. Clarifying the targets and molecular mechanisms underlying TCM compounds is essential for scientifically validating TCM's therapeutic roles in disease prevention and treatment, as well as for identifying novel therapeutic targets and lead compounds.
View Article and Find Full Text PDFGyosaponin ameliorates sevoflurane anesthesia-induced cognitive dysfunction and neuronal apoptosis in rats through modulation of the PI3K/AKT/mTOR pathway.
Clinics (Sao Paulo)
December 2024
Department of Anesthesia, Central People's Hospital of Zhanjiang, Zhanjiang City, Guangdong Province, PR China. Electronic address:
Background: Sevoflurane (Sev) is an inhalational anesthetic for surgical procedures where it can trigger cognitive dysfunction and neuronal apoptosis. Gyosaponin (GpS) was studied for its effects on brain morphology and cognitive behaviors in Sev-anesthetized rats.
Methods: Male Sprague-Dawley rats were induced by 3 % Sev anesthesia, and 25 mg/kg and 100 mg/kg GpS were injected into the rats by tail vein.
Preparation of Rare Dehydrated Protopanaxadiol Ginsenosides from Leaves by Confined Microwave-Driven Transformation.
J Agric Food Chem
January 2025
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao 999078, P.R. China.
Rare dehydrated ginsenosides barely exist in natural ginseng plants. Herein, the confined microwave technique was utilized to transform the main ginsenosides of leaves (PNL) into dehydrated ginsenosides. The main microwave-treated products of dried PNL are dehydrated ginsenoside Rk1, Rg5, notoginsenoside SFt3, and SFt4.
View Article and Find Full Text PDFEnrichment of Ginseng Rare Sapogenin 25-OH-PPT and Its Protective Effect on Myocardial Fibrosis.
Molecules
December 2024
School of Functional Food & Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Article Synopsis
- Ginseng contains rare compounds called ginsenosides, specifically 25-OH-PPT (T19), known for beneficial effects like lowering blood sugar and reducing inflammation.
- The research focused on optimizing the process to extract T19 from ginseng stems and leaves, utilizing different acids and hydrolysis conditions to maximize yield safely.
- Results showed that hydrochloric acid increased T19 content significantly, while citric acid was safer; additionally, T19 demonstrated protective effects on heart cells by reducing oxidative stress and impacting fibrosis markers.
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