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Inverse dose protraction effects of low-LET radiation: evidence and significance.
Mutat Res Rev Mutat Res
January 2025
Radiation Epidemiology Branch, National Cancer Institute, MD 20892-9778, USA; Faculty of Health, Science and Technology, Oxford Brookes University, Headington Campus, OX3 0BP, UK.
Biological effects of ionizing radiation vary not merely with total dose but also with temporal dose distribution. Sparing dose protraction effects, in which dose protraction reduces effects of radiation have widely been accepted and generally assumed in radiation protection, particularly for stochastic effects (e.g.
View Article and Find Full Text PDFRevisiting the safety limit in magnetic nanoparticle hyperthermia: insights from eddy current induced heating.
Phys Med Biol
January 2025
Department of Physics, Aristotle University of Thessaloniki, University Campus, Thessaloniki, 54124, GREECE.
Magnetic nanoparticle hyperthermia (MNH) emerges as a promising therapeutic strategy for cancer treatment, leveraging alternating magnetic fields (AMFs) to induce localized heating through magnetic nanoparticles (MNPs). However, the interaction of AMFs with biological tissues leads to non-specific heating caused by eddy currents, triggering thermoregulatory responses and complex thermal gradients throughout the body of the patient. While previous studies have implemented the Atkinson-Brezovich limit to mitigate potential harm, recent research underscores discrepancies between this threshold and clinical outcomes, necessitating a re-evaluation of this safety limit.
View Article and Find Full Text PDFEffects of ionizing radiation on osteoblastic cells: In vitro insights into the etiopathogenesis of osteoradionecrosis.
Arch Oral Biol
December 2024
University of Brasília, Brasília, Laboratory of Oral Histopathology, Health Sciences Faculty, Brazil. Electronic address:
Objective: This in vitro study aimed to analyze the effects of ionizing radiation on immortalized human osteoblast-like cells (SaOS-2) and further assess their cellular response in co-culture with fibroblasts. These analyses, conducted in both monoculture and co-culture, are based on two theoretical models of osteoradionecrosis - the theory of hypoxia and cellular necrosis and the theory of the radiation-induced fibroatrophic process.
Design: SaOS-2 cells were exposed to ionizing radiation and evaluated for cell viability, nitric oxide (NO) production, cellular morphology, wound healing, and gene expression related to the PI3K-AKT-mTOR pathway.
Engineered Cell Microenvironments: A Benchmark Tool for Radiobiology.
ACS Appl Mater Interfaces
January 2025
Department of Precision and Microsystems Engineering, Faculty of Mechanical Engineering, Delft University of Technology, Mekelweg 2, 2628 CD Delft, The Netherlands.
The development of engineered cell microenvironments for fundamental cell mechanobiology, in vitro disease modeling, and tissue engineering applications increased exponentially during the last two decades. In such context, in vitro radiobiology is a field of research aiming at understanding the effects of ionizing radiation (e.g.
View Article and Find Full Text PDFClinical consequence of the 4-week X-ray control after ESIN osteosynthesis of forearm fractures in children.
Eur J Trauma Emerg Surg
January 2025
Department of Orthopaedics and Traumatology, University Medical Center of the Johannes Gutenberg University, 55131, Mainz, Germany.
Purpose: The absence of evidence based general guidelines for radiographic follow-ups of pediatric diaphyseal forearm fractures treated with ESIN results in an arbitrary array of X-ray examinations. In most pediatric traumatology departments, an X-ray check is carried out 4 weeks after ESIN osteosynthesis of forearm shaft fractures to detect incipient consolidation of the fracture. However, the elevated sensitivity to ionizing radiation requires special precautions in the pediatric populations.
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