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Pricing for Multi-Indication Drugs in the Italian Regulatory Context.
Pharmacoecon Open
January 2025
HTA & Pharmaceutical Economics Department, Italian Medicines Agency (AIFA), Rome, Italy.
Background: The authorization of new therapeutic indications for drugs already reimbursed by the Italian National Health Service (NHS) represents a matter of importance. This study aims to estimate the additional discount attributed to the extension of indications (EoIs) to explore the potential correlation between spending and negotiated discounts and to find specific factors (determinants) that impact on discount.
Methods: The study focused on drugs approved in Italy between 2003 and 2017 with at least four therapeutic indications, including the first approved and EoIs, with follow-up extended until 2021 to acquire all the information on the negotiation process that has been completed.
A Narrative Review of Cardiometabolic Profiles among U.S. Adults: Temporal Trends and Implications.
Curr Cardiol Rep
January 2025
John Ochsner Heart and Vascular Institute, Ochsner Clinical School University of Queensland School of Medicine, New Orleans, LA, USA.
Purpose Of Review: To provide a narrative overview of trends and disparities in the cardiometabolic profiles of U.S. adults by synthesizing findings from nationally representative studies conducted between 1999 and 2020.
View Article and Find Full Text PDFNutritional and Functional Characterization of Chia Expeller and Gluten-Free Flours as Ingredients for Premixes.
Plant Foods Hum Nutr
January 2025
UNCPBA, Facultad de Ingeniería, Departamento de Ingeniería Química y Tecnología de los Alimentos, TECSE, Olavarría, Buenos Aires, Argentina.
The growing consumer demand for healthier foods that help reduce the risk of chronic diseases has driven the food industry to innovate with nutritionally and technologically viable products. This trend and the nutritional gaps in gluten-free diets have spurred the exploration of unconventional, high-quality ingredients like flour from pseudocereals, legumes, and oilseeds. This study evaluated the nutritional and functional profiles of chia expeller and flours from buckwheat, green/yellow peas, and rice to study their potential as techno-functional ingredients for new gluten-free premixes.
View Article and Find Full Text PDFAssociation of Self-Recognition of Hearing Loss With Hospitalizations in Older Adults in the United States.
Med Care
January 2025
Cochlear Center for Hearing and Public Health, Johns Hopkins University, Baltimore, MD.
Background: Hearing loss is highly prevalent and associated with increased health care utilization. Recognition of hearing loss may play an important role in self-advocacy in difficult communication situations and prevent negative outcomes.
Objectives: To investigate the associations between self-recognition of hearing loss and hospitalization outcomes.
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