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α-amanitin induces hepatotoxicity via PPAR-γ inhibition and NLRP3 inflammasome activation.
Ecotoxicol Environ Saf
January 2025
Department of Forensic Medicine, School of Forensic Medicine, Kunming Medical University, Kunming, China. Electronic address:
Mushroom poisoning, predominantly caused by α-amanitin, is a critical food safety concern in worldwide, with severe cases leading to hepatotoxicity and fatalities. This study delves into the hepatotoxic effects of α-amanitin, focusing on the NLRP3 inflammasome and PPAR-γ's regulatory role in inflammation. In vitro studies with L-02 cells showed that α-amanitin reduces cell viability and triggers NLRP3 inflammasome activation, increasing NF-κB phosphorylation and pro-inflammatory cytokines IL-18 and IL-1β.
View Article and Find Full Text PDFEpidemiological and Clinical Characteristics of Pediatric Acute Drug Intoxications: A Retrospective Analysis.
Children (Basel)
December 2024
County Hospital Craiova, Department of Anatomy, University of Medicine and Pharmacy, Discipline of Anatomy, 200349 Craiova, Romania.
Background/objectives: Acute drug intoxications (ADIs) are a significant concern in pediatric healthcare, contributing to both accidental and intentional morbidity. This study aimed to analyze the demographic, clinical, and therapeutic characteristics of pediatric ADI cases to identify trends and inform preventive strategies.
Methods: This retrospective study included 120 cases of pediatric ADI admitted to the Second Pediatric Clinic of Craiova County Emergency Clinical Hospital in 2022 and 2023.
Determination of Puberulic Acid in Monascus-Fermented Red Yeast Rice by LC-MS/MS Combined with Precolumn Derivatization.
Toxins (Basel)
December 2024
NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai Institute for Food and Drug Control, 1500 Zhangheng Road, Shanghai 201203, China.
Puberulic acid (PA) is a mycotoxin produced by a species of . It has received widespread attention as a significant contributor to the reported fatalities associated with red yeast rice dietary supplements. However, the detection of PA, especially at low concentration levels, poses a considerable challenge, with no detection methods reported thus far.
View Article and Find Full Text PDFA Review of Intermittent Poisoning to Mitigate Toxic Plant-Induced Disease in Livestock.
Vet Sci
December 2024
Poisonous Plant Research Laboratory, USDA Agricultural Research Service, Logan, UT 84341, USA.
Poisonous plants affect livestock and wildlife and in addition to animal disease, they often inhibit the productive use of feeds and natural resources. For some plants, intermittent or cyclic grazing may allow the use of contaminated forages or infested pastures or ranges while avoiding permanent effects of poisoning. The objective of this review is to present several toxic plants for which intermittent poisoning might be an effective management tool.
View Article and Find Full Text PDFShould digoxin immune fab be administered based solely on reported ingested amount in acute digoxin poisoning?
Am J Emerg Med
January 2025
Minnesota Regional Poison Center, Department of Pharmacy, Hennepin Healthcare, Minneapolis, MN, USA; Department of Family Medicine and Biobehavioral Health, University of Minnesota Medical School, Duluth Campus, Duluth, MN, USA. Electronic address:
Acute digoxin poisoning is increasingly uncommon in emergency medicine. Furthermore, controversy exists regarding indications for antidotal digoxin immune fab in acute poisoning. In healthy adults, the fab prescribing information recommends administration based on "known consumption of fatal doses of digoxin: ≥10mg," while many emergency medicine textbooks suggest fab administration be driven by clinical features or potassium concentration.
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