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AAPM Task Group Report 274: Fluence rate dosimetry for photodynamic therapy (PDT).
Med Phys
January 2025
Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, NKI-AvL, Amsterdam, Netherlands.
Photodynamic therapy (PDT) is a treatment modality clinically approved for several oncologic indications, including esophageal and endobronchial cancers, precancerous conditions including Barrett's esophagus and actinic keratosis, and benign conditions like age-related macular degeneration. While it is currently clinically underused, PDT is an area of significant research interest. Because PDT relies on the absorption of light energy by intrinsic or administered absorbers, the dosimetric quantity of interest is the absorbed energy per unit mass of tissue, proportional to the fluence rate of light in tissue.
View Article and Find Full Text PDFEffective Radiation Dose from Cone-Beam Computed Tomography Guidance during Bronchoscopic Tumour Ablation.
Respiration
August 2024
Department of Respiratory and Sleep Medicine, Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Article Synopsis
- Endobronchial radiofrequency ablation (RFA) offers a minimally invasive treatment for patients with peripheral non-small-cell lung cancer (NSCLC) who cannot undergo surgery, with procedures guided by cone-beam computed tomography (CBCT).
- The study analyzed data from ten patients who underwent bronchoscopic RFA, calculating their radiation exposure using PCXMC2.0 software and evaluating the amount of radiation received during CBCT imaging.
- Results showed that the average effective radiation dose was about 11.6 mSv, which is similar to radiation levels from other CT-guided procedures, highlighting the safety of this technique in managing NSCLC.
Systematic endoscopic staging of mediastinum to guide radiotherapy planning in patients with locally advanced non-small-cell lung cancer (SEISMIC): an international, multicentre, single-arm, clinical trial.
Lancet Respir Med
June 2024
The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia; Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Article Synopsis
- Systematic mediastinal lymph node staging using EBUS-TBNA helps in accurately identifying lymph node metastases in early-stage non-small-cell lung cancer (NSCLC), but its effectiveness in locally advanced cases is less understood.
- A study across four countries evaluated locally advanced NSCLC patients to see how often systematic staging revealed hidden (PET-occult) lymph node metastases before treatment.
- Out of 155 patients, 12% were found to have PET-occult metastases, with significant implications for treatment planning and radiotherapy decisions.
Ten fraction hypofractionated stereotactic body radiotherapy for the management of ultracentral lung tumors: a retrospective analysis of dosimetry, outcomes, and toxicity.
Radiat Oncol
August 2023
Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, KS, USA.
Background: The management of ultracentral thoracic tumors with ablative dose of radiotherapy remains challenging given proximity to critical central structures. We report patient outcomes, toxicity, and dosimetry for ultracentrally located tumors with hypofractionated stereotactic body radiotherapy (hfSBRT).
Methods: Seventy-eight individuals (50 initial radiotherapy, 28 re-irradiation) undergoing 10 fraction hfSBRT for ultracentrally located thoracic tumors treated between 2009 and 2020 at a single institution were retrospectively reviewed.
First-In-Human Computer-Optimized Endobronchial Ultrasound-Guided Interstitial Photodynamic Therapy for Patients With Extrabronchial or Endobronchial Obstructing Malignancies.
JTO Clin Res Rep
October 2022
Department of Cell Stress Biology, Photodynamic Therapy Center, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Objective: Patients with inoperable extrabronchial or endobronchial tumors who are not candidates for curative radiotherapy have dire prognoses with no effective long-term treatment options. To reveal that our computer-optimized interstitial photodynamic therapy (I-PDT) is safe and potentially effective in the treatment of patients with inoperable extra or endobronchial malignancies inducing central airway obstructions.
Methods: High-spatial resolution computer simulations were used to personalize the light dose rate and dose for each tumor.
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