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RSV Vaccine with Nanoparticle-Based Poly-Sorbitol Transporter (PST) Adjuvant Improves Respiratory Protection Against RSV Through Inducing Both Systemic and Mucosal Humoral Immunity.
Vaccines (Basel)
November 2024
Department of Systems Biotechnology, Chung-Ang University, Anseong 17456, Republic of Korea.
Respiratory syncytial virus (RSV) causes symptoms similar to a mild cold for adults, but in case of infants, it causes bronchitis and/or pneumonia, and in some cases, mortality. Mucosal immunity within the respiratory tract includes tissue-resident memory T (T) cells and tissue-resident memory B (B) cells, which provides rapid and efficient protection against RSV re-infection. Therefore, vaccine strategies should aim to generate mucosal immune responses.
View Article and Find Full Text PDFIs pancreatitis associated with meglumine antimoniate treatment for canine leishmaniosis? A multicentric prospective study.
Parasit Vectors
December 2024
Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Background: Meglumine antimoniate is used to treat canine leishmaniosis. In humans, it has been associated with pancreatitis. Although a few case reports have described acute pancreatitis secondary to antimonial treatment in dogs, some studies have concluded that pancreatitis is not an adverse effect of this medication.
View Article and Find Full Text PDFNew immunomodulatory treatment protocol for canine leishmaniosis reduces parasitemia and proteinuria.
PLoS Negl Trop Dis
December 2024
Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, Bellaterra, Spain.
The current standard treatment for canine leishmaniosis (CanL), N-methylglucamine antimoniate (MGA) given with allopurinol, is not fully effective and may cause adverse effects and drug resistance. In vitro and in vivo studies have shown that nucleotides, administered alone or with AHCC, offer benefits in the treatment of CanL. This study examines the effects of a new immunomodulatory treatment protocol in which dietary nucleotides and AHCC are added to the recommended standard treatment.
View Article and Find Full Text PDFDevelopment of a thermal stabilizer formulation optimized by response surface methodology for Senecavirus A antigen.
J Pharm Sci
December 2024
School of Tropical Agriculture and Forestry, Hainan University, 570228, Haikou, China. Electronic address:
Numerous members of the family Picornaviridae, such as the Senecavirus A (SVA) and foot-and-mouth disease virus (FMDV), exhibit thermal instability, resulting in the dissociation of viral particles, which affects the insufficient potency of the vaccine. Based on this characteristic, this study aimed to maintain the thermal stability of SVA by supplementing it with a stabilizer. Excipients, such as sucrose, mannitol, sorbitol, polyethylene glycol (PEG), L-arginine (L-Arg), glutamic acid (Glu), polyvinyl pyrrolidone (PVP), bovine serum albumin (BSA), and potassium chloride (KCl) dissolved in Tris-HCl buffer solution, retained the infectivity of SVA in the thermostability assay.
View Article and Find Full Text PDFOxidative Stress Biomarkers and Metabolic Parameters in Healthy Holstein Dairy Cows and Cows With Left Displacement Abomasum During the Transitional Period.
Vet Med Sci
January 2025
Professor of Veterinary Surgery and Radiology, Department of Veterinary Surgery and Radiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Article Synopsis
- Dairy cows undergoing the transitional period are more prone to oxidative stress and diseases like left displacement of the abomasum (LDA).
- The study compared blood biomarker levels between cows with LDA and healthy cows to understand the connections between oxidative stress and metabolic changes.
- Results indicated that cows with LDA had significantly higher levels of various metabolites and oxidative stress indicators, suggesting a link between oxidative stress and the health issues observed in these animals.
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