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Beyond Fang's fury: a computational study of the enzyme-membrane interaction and catalytic pathway of the snake venom phospholipase A toxin.
Chem Sci
January 2025
LAQV/Requimte, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto Rua do Campo Alegre, s/n 4169-007 Porto Portugal
Snake venom-secreted phospholipases A (svPLAs) are critical, highly toxic enzymes present in almost all snake venoms. Upon snakebite envenomation, svPLAs hydrolyze cell membrane phospholipids and induce pathological effects such as paralysis, myonecrosis, inflammation, or pain. Despite its central importance in envenomation, the chemical mechanism of svPLAs is poorly understood, with detrimental consequences for the design of small-molecule snakebite antidotes, which is highly undesirable given the gravity of the epidemiological data that ranks snakebite as the deadliest neglected tropical disease.
View Article and Find Full Text PDFCorrelation of lipid hydrolysis, oxidation, and molecular transformation with volatile compound revolution in pork during postmortem wet-aging process.
Food Chem
December 2024
Key Laboratory of Agricultural Product Processing and Quality Control (Co-construction by Ministry and Province), Beijing University of Agriculture, Beijing 102206, PR China.
Lipid hydrolysis and oxidation properties, lipid metabolites, and volatile flavors were investigated to elucidate the wet-aging process (1 h to 10 d) on lipid molecule transformation and volatile flavor evolution in pork. Phospholipase A (PLA) activity increased at 12 h, with lipoxygenase (LOX) increasing from 1 h to 7 d (P < 0.05).
View Article and Find Full Text PDFChondroitin sulfate (CS), a glycosaminoglycan, supports health through various physiological functions, including tissue protection, bone growth, and skin aging prevention. It also contributes to anticoagulant or anti-inflammatory processes, with its primary clinical use being osteoarthritis treatment. This study presents the results of the valorization of lipids and CS, both extracted from salmon co-products through enzymatic processes.
View Article and Find Full Text PDFHippo pathway activation causes multiple lipid derangements in a murine model of cardiomyopathy.
Biochim Biophys Acta Mol Cell Biol Lipids
December 2024
Department of Cardiology, Shaanxi Provincial Hospital, Xi'an, China; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University Health Science Center, Xi'an, China; Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. Electronic address:
Metabolic reprogramming occurs in cardiomyopathy and heart failure contributing to progression of the disease. Activation of cardiac Hippo pathway signaling has been implicated in mediating mitochondrial dysfunction and metabolic reprogramming in cardiomyopathy, albeit influence of Hippo pathway on lipid profile is unclear. Using a dual-omics approach, we determined alterations of cardiac lipids in a mouse model of cardiomyopathy due to enhanced Hippo signaling and explored molecular mechanisms.
View Article and Find Full Text PDFMembrane-Bound Bisindolyl-Based Chromogenic Probes: Analysis of Cyanogenic Glycosides in Agricultural Crops for Possible Remediation.
ACS Appl Bio Mater
December 2024
Department of Chemistry, Birla Institute of Technology and Science Pilani, Hyderabad, Telangana 500078, India.
Cyanogenic glycosides are plant-derived, nitrogen-containing secondary metabolites that release toxic cyanide ions upon hydrolysis by glycosidic enzymes. Therefore, consuming food items enriched with such compounds without proper remediation can cause acute cyanide intoxication. Thus, in this work, we utilize cyanide-responsive oxidized bisindole-based chromogenic probes to detect cyanogenic glycosides, such as amygdalin and linamarin (LOD: 0.
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