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Hypothesis on the outflow of optic nerve cerebrospinal fluid in spaceflight associated neuro ocular syndrome.
NPJ Microgravity
December 2024
University of Shanghai for Science and Technology, Shanghai, China.
Spaceflight-associated neuro-ocular syndrome (SANS) has been well documented in astronauts. However, its pathogenesis is not fully understood. New findings indicate the impaired outflow of the optic nerve cerebrospinal fluid may participate or contribute to some changes in SANS.
View Article and Find Full Text PDFThe ground reaction force pattern during walking under vestibular-demanding task with/without mastoid vibration: implication for future sensorimotor training in astronauts.
Front Physiol
November 2024
Independent Researcher, Omaha, NE, United States.
Background: The Sensory Organization Test condition 5 (SOT5) assesses an astronaut's vestibular function pre-/post-spaceflight but has a ceiling effect and mainly evaluates standing balance, neglecting the challenges of walking during space missions. A Locomotor Sensory Organization Test (LSOT) has been developed, mirroring the SOT concept but tailored to assess vestibular function during walking. This study aims to advance current knowledge by examining changes in ground reaction force (GRF) during normal walking (LSOT1) and walking in LSOT5 (vision blocked and treadmill speed varied), both with and without mastoid vibrations.
View Article and Find Full Text PDFThe effects of 15-day complete fasting on the attentional network: An ERP study.
Brain Res
February 2025
China Astronaut Research and Training Center, Beijing 100094, China. Electronic address:
This study examined whether and how a 15-day complete fast affects attentional network function. During a 15-day complete fasting, 17 healthy participants completed an attentional network test, while behavioral and EEG data were obtained. EEG results were marginally significant for the interaction between fasting stages and cue hints on the N1 amplitude of the altering network (F = 2.
View Article and Find Full Text PDFFuture space exploration missions will expose astronauts to various stressors, making the early detection of mental stress crucial for prolonged missions. Our study proposes using functional near infrared spectroscopy (fNIRS) combined with multiple machine learning models to assess the level of mental stress. The objective is to identify and quantify stress levels during 240 days confinement scenario.
View Article and Find Full Text PDFTranscriptomic analysis of embryonic mouse hypothalamic N38 cells exposed to high-energy protons and/or simulated microgravity.
Heliyon
October 2024
Inha Institute of Aerospace Medicine, Inha University College of Medicine, Incheon, 22332, Republic of Korea.
Article Synopsis
- Space exploration presents challenges for astronauts due to the impacts of space radiation and microgravity, prompting a study on how these factors affect gene expression in mouse hypothalamic cells (N38).
- The study used four experimental groups to analyze transcriptomic changes, identifying 355 differentially expressed genes, with certain genes consistently upregulated across multiple experimental conditions.
- The findings highlight complex molecular responses that could inform health risk mitigation strategies for astronauts during long-duration space missions.
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