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Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer's disease.
Nat Commun
January 2025
Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Studies of the genetics of Alzheimer's disease (AD) have largely focused on single nucleotide variants and short insertions/deletions. However, most of the disease heritability has yet to be uncovered, suggesting that there is substantial genetic risk conferred by other forms of genetic variation. There are over one million short tandem repeats (STRs) in the genome, and their link to AD risk has not been assessed.
View Article and Find Full Text PDFFactors associated with mortality in thoracic trauma patients in Cameroon.
Heliyon
January 2025
Data Science Center for the Study of Surgery, Injury, and Equity in Africa (D-SINE-Africa), University of Buea, Cameroon.
Background: Thoracic trauma is the third most common cause of death after abdominal injury and head trauma in polytrauma patients. The identification of a patient at risk of thoracic trauma mortality is necessary to avoid delays that may lead to morbidity and mortality. Therefore, the objective was to assess the factors associated with mortality among thoracic trauma patients in Cameroon.
View Article and Find Full Text PDFASRA Pain Medicine consensus practice infection control guidelines for regional anesthesia and pain medicine.
Reg Anesth Pain Med
January 2025
Division of Pain Management, University Hospitals, Cleveland, Ohio, USA.
Background: To provide recommendations on risk mitigation, diagnosis and treatment of infectious complications associated with the practice of regional anesthesia, acute and chronic pain management.
Methods: Following board approval, in 2020 the American Society of Regional Anesthesia and Pain Medicine (ASRA Pain Medicine) commissioned evidence-based guidelines for best practices for infection control. More than 80 research questions were developed and literature searches undertaken by assigned working groups comprising four to five members.
Identifying Strong Neoantigen MHC-I/II Binding Candidates for Targeted Immunotherapy with SINE.
Int J Mol Sci
December 2024
Moores Cancer Center, University of California San Diego, San Diego, CA 92037, USA.
The discovery of tumor-derived neoantigens which elicit an immune response through major histocompatibility complex (MHC-I/II) binding has led to significant advancements in immunotherapy. While many neoantigens have been discovered through the identification of non-synonymous mutations, the rate of these is low in some cancers, including head and neck squamous cell carcinoma. Therefore, the identification of neoantigens through additional means, such as aberrant splicing, is necessary.
View Article and Find Full Text PDFModelling mixed crop-livestock systems and climate impact assessment in sub-Saharan Africa.
Sci Rep
January 2025
Institute of Crop Science and Resource Conservation, University of Bonn, Katzenburgweg 5, D-53115, Bonn, Germany.
Climate change significantly challenges smallholder mixed crop-livestock (MCL) systems in sub-Saharan Africa (SSA), affecting food and feed production. This study enhances the SIMPLACE modeling framework by incorporating crop-vegetation-livestock models, which contribute to the development of sustainable agricultural practices in response to climate change. Applying such a framework in a domain in West Africa (786,500 km) allowed us to estimate the changes in crop (Maize, Millet, and Sorghum) yield, grass biomass, livestock numbers, and greenhouse gas emission in response to future climate scenarios.
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