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STUDY OF BIOLOGICAL EFFECTS OF TRITIUM IN MICE.
Radiat Prot Dosimetry
September 2022
Radioisotope Research Center, University of Occupational and Environmental Health, Japan.
The mutation, apoptosis and chromosomal aberration induced by tritiated water (HTO) in spleen T lymphocytes of mice were investigated and compared with those by acute or chronic 137Cs gamma irradiation. p53 wild-type (p53+/+) and null (p53-/-) mice were exposed to tritium (3H) beta rays via a single injection of HTO. 137Cs gamma irradiation was carried out at dose-rate of 0.
View Article and Find Full Text PDFThe low dose effects of human mammary epithelial cells induced by internal exposure to low radioactive tritiated water.
Toxicol In Vitro
December 2019
Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900, PR China.
Tritium is an important radioactive waste which needs to be monitored for radiation protection. Due to long biological half-life of organically bound tritium (OBT), the adverse consequence caused by chronic exposure of tritiated water (HTO) attracts concern. In this study, fibroblast cells were exposed to 2 × 10 Bq/ml HTO to investigate the cellular behaviors.
View Article and Find Full Text PDFIn vivo animal studies help achieve international consensus on standards and guidelines for health risk estimates for chronic exposure to low levels of tritium in drinking water.
Environ Mol Mutagen
August 2018
Radiobiology and Health, Canadian Nuclear Laboratories, Chalk-River, ON, Canada.
Existing and future nuclear fusion technologies involve the production and use of large quantities of tritium, a highly volatile, but low toxicity beta-emitting isotope of hydrogen. Tritium has received international attention because of public and scientific concerns over its release to the environment and the potential health impact of its internalization. This article provides a brief summary of the current state of knowledge of both the biological and regulatory aspects of tritium exposure; it also explores the gaps in this knowledge and provides recommendations on the best ways forward for improving our understanding of the health effects of low-level exposure to it.
View Article and Find Full Text PDFIs bacterial luminescence response to low-dose radiation associated with mutagenicity?
J Environ Radioact
October 2017
Siberian Federal University, 79 Svobodny Prospect, Krasnoyarsk, 660041, Russia; Institute of Biophysics SB RAS, Federal Research Center 'Krasnoyarsk Science Center SB RAS', 50/50 Akademgorodok, Krasnoyarsk, 660036, Russia. Electronic address:
Luminous marine bacteria are widely used in bioassays with luminescence intensity being a physiological parameter tested. The purpose of the study was to determine whether bacterial genetic alteration is responsible for bioluminescence kinetics change under low-dose radiation exposure. The alpha-emitting radionuclide Am and beta-emitting radionuclide H were used as the sources of low-dose ionizing radiation.
View Article and Find Full Text PDFExposure to tritiated water at an elevated temperature: Genotoxic and transcriptomic effects in marine mussels (M. galloprovincialis).
J Environ Radioact
November 2016
School of Biological Sciences, Plymouth University, Drake Circus, Plymouth, PL4 8AA, UK. Electronic address:
Temperature is an abiotic factor of particular concern for assessing the potential impacts of radionuclides on marine species. This is particularly true for tritium, which is discharged as tritiated water (HTO) in the process of cooling nuclear institutions. Additionally, with sea surface temperatures forecast to rise 0.
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