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Strategies for development of potential candidate Shigella vaccines.
Vaccine
March 1993
Karolinska Institute, Department of Clinical Bacteriology, Huddinge Hospital, Sweden.
Bacillary dysentery, caused by Shigella bacteria, is a major enteric disease responsible for over 200 million infections annually with 650,000 fatal cases. Due to its high communicability, improvement of hygienic standards alone should reduce the spread of dysentery. However, such measures are expensive, and in the communities (e.
View Article and Find Full Text PDFCloning of the rfb gene region of Shigella dysenteriae 1 and construction of an rfb-rfp gene cassette for the development of lipopolysaccharide-based live anti-dysentery vaccines.
Microb Pathog
June 1986
Department of Medical Biochemistry, University Medical Centre, University of Geneva, Switzerland.
Recent studies have shown that determinants for the production of O antigen lipopolysaccharide in Shigella dysenteriae 1 are distributed over two distinct genetic elements, the chromosome and a 9 kb plasmid designated pHW400. In this communication, we describe the cloning of all determinants necessary for S. dysenteriae 1 O antigen production in E.
View Article and Find Full Text PDF[Studies of dysenteric infection in a closed children's community before and after anti-dysentery vaccination. II. Data on the response to antibiotics and chemotherapy].
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol
December 1980
Study of the behaviour to 7 antibiotics and chemotherapeutics of the Shigella and E. coli strains, isolated from the feces samples of children and adults in a closed community, revealed the high incidence of multiple resistance, especially to the currently used drugs tested. The existence of the phenomenon of plasmid transferable resistance in commensal or pathogenic E.
View Article and Find Full Text PDF[Treatment of chronic bacillary dysentery using a live anti-dysentery vaccine].
Arch Roum Pathol Exp Microbiol
March 1973
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