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The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial.
Trials
January 2025
Cardiology Department, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041, People's Republic of China.
Background: Resistant hypertension (RH) is defined as uncontrolled blood pressure (BP) despite treatment with at least three or more antihypertensive agents. Compelling evidence has shown that such a population has a greater risk of cardiovascular events as well as mortality. Although mineralocorticoid receptor antagonists (MRAs) have been shown to be an effective fourth-line treatment for RH, a significant proportion of RH patients do not achieve their blood pressure target.
View Article and Find Full Text PDFIn Silico Analysis of Triamterene as a Potential Dual Inhibitor of VEGFR-2 and c-Met Receptors.
J Xenobiot
December 2024
Cancer Biology and Therapy Laboratory, School of Applied and Health Sciences, London South Bank University, London SE1 0AA, UK.
The vascular endothelial growth factor receptor 2 (VEGFR2) and the hepatocyte growth factor receptor (C-Met) are critical receptors for signaling pathways controlling crucial cellular processes such as cell growth, angiogenesis and tissue regeneration. However, dysregulation of these proteins has been reported in different diseases, particularly cancer, where these proteins promote tumour growth, invasiveness, metastasis and resistance to conventional therapies. The identification of dual inhibitors targeting both VEGFR-2 and c-Met has emerged as a strategic therapeutic approach to overcome the limitations and resistance mechanisms associated with single-target therapies in clinical settings.
View Article and Find Full Text PDFLiddle Syndrome with a SCNN1A Mutation: A Case Report and Literature Review.
Kidney Blood Press Res
October 2024
Department of Endocrinology and Metabolism, The Second People's Hospital of Guiyang, Guiyang, China.
Article Synopsis
- Liddle syndrome is a genetic condition that causes early-onset high blood pressure, low potassium levels, and other hormonal imbalances due to mutations in genes responsible for sodium channels, primarily SCNN1A.
- A case from China involved a 59-year-old man with a long history of uncontrolled hypertension and low potassium, which was linked to a rare mutation in the SCNN1A gene identified through genetic testing.
- The patient showed significant improvement in potassium levels and blood pressure after treatment with triamterene, highlighting the importance of genetic testing in diagnosing conditions like Liddle syndrome.
Increase in bile acids after sleeve gastrectomy improves metabolism by activating GPBAR1 to increase cAMP in mice with nonalcoholic fatty liver disease.
Immun Inflamm Dis
July 2024
Department of Gastrointestinal Hepatobiliary Surgery, The Affiliated Hospital of Hangzhou Normal University, Hangzhou City, China.
Background: Bile acids (BAs) concentration can affect metabolic improvement caused by bariatric surgery and BA concentrations increase in patients after sleeve gastrectomy (SG). Here, how BAs after SG affect metabolism in nonalcoholic fatty liver disease (NAFLD) was studied.
Methods: Mice were given high-fat diet (HFD) to induce NAFLD and received SG surgery.
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