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Genomics yields biological and phenotypic insights into bipolar disorder.
Nature
January 2025
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFAn exploratory study on the effect of rescuer team size on basic and advanced life support technical skills in a high-fidelity simulation of canine cardiopulmonary arrest.
J Vet Emerg Crit Care (San Antonio)
January 2025
Center for Interdisciplinary Statistical Education and Research, Washington State University, Pullman, Washington, USA.
Objective: To evaluate the effect of rescuer team size on objective skill measures of basic life support (BLS) and advanced life support (ALS) using high-fidelity canine CPR simulation.
Design: Prospective, experimental study.
Setting: Veterinary clinical simulation center.
Phase transition in magic with random quantum circuits.
Nat Phys
January 2024
Joint Center for Quantum Information and Computer Science, University of Maryland and NIST, College Park, MD 20742.
Magic is a property of quantum states that enables universal fault-tolerant quantum computing using simple sets of gate operations. Understanding the mechanisms by which magic is created or destroyed is, therefore, a crucial step towards efficient and practical fault-tolerant computation. We observe that a random stabilizer code subject to coherent errors exhibits a phase transition in magic, which we characterize through analytic, numeric and experimental probes.
View Article and Find Full Text PDFThe ENIGMA-Neuromodulation Working Group - A Mission Statement.
Brain Stimul
January 2025
Assistant Professor Co-Director, Center for Psychedelic Research and Therapy Department of Psychiatry & Behavioral Sciences Dell Medical School The University of Texas at Austin.
Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels.
Elife
January 2025
Department of Otorhinolaryngology - Head & Neck Surgery, University of Maryland School of Medicine, Baltimore, United States.
Calcium and integrin-binding protein 2 (CIB2) and CIB3 bind to transmembrane channel-like 1 (TMC1) and TMC2, the pore-forming subunits of the inner-ear mechano-electrical transduction (MET) apparatus. These interactions have been proposed to be functionally relevant across mechanosensory organs and vertebrate species. Here, we show that both CIB2 and CIB3 can form heteromeric complexes with TMC1 and TMC2 and are integral for MET function in mouse cochlea and vestibular end organs as well as in zebrafish inner ear and lateral line.
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