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Multi-Institutional Comparison of Quality of Life Between Open Versus Endoscopic Skull Base Approaches.
Laryngoscope Investig Otolaryngol
February 2025
Department of Otolaryngology Head and Neck Surgery, Sinai Health Systems University of Toronto Toronto Ontario Canada.
Objectives: The primary objective of this prospective review was to compare quality of life between patients undergoing endoscopic and open skull base approaches.
Study Type And Design: Prospective Review.
Methods: Five centers recruited consecutive patients treated surgically for skull base neoplasms between 2012 to 2018.
Baseline Clinical Factors Associated with Cessation of Growth Hormone Therapy in Patients with Severe Growth Hormone Deficiency - Real World Evidence.
Int J Endocrinol Metab
July 2024
Allam Diabetes Centre, Hull University Teaching Hospitals NHS Foundation Trust, Hull, UK.
Background: Growth hormone replacement is indicated in adults with severe growth hormone (GH) deficiency, adult growth hormone deficiency assessment (AGHDA) score of at least 11 and are receiving treatment for other pituitary hormone deficiencies. There are no data looking at the cessation of GH replacement in adult patients with severe GH deficiency and the factors that predict the likelihood of patients continuing or stopping growth hormone replacement.
Methods: We audited patients on the GH register between January 2006 and January 2023 in Hull University Teaching Hospitals NHS foundation Trust, a UK tertiary hospital.
Flavins and Flavoproteins in the Neuroimmune Landscape of Stress Sensitization and Major Depressive Disorder.
J Inflamm Res
January 2025
Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Jupiter, FL, USA.
Major Depressive Disorder (MDD) is a common and severe neuropsychiatric condition resulting in irregular alterations in affect, mood, and cognition. Besides the well-studied neurotransmission-related etiologies of MDD, several biological systems and phenomena, such as the hypothalamic-pituitary-adrenal (HPA) axis, reactive oxygen species (ROS) production, and cytokine signaling, have been implicated as being altered and contributing to depressive symptoms. However, the manner in which these factors interact with each other to induce their effects on MDD development has been less clear, but is beginning to be understood.
View Article and Find Full Text PDFAtypical Thyroid Stimulating Hormone Levels in Myxedema Coma Complicated by Severe Sepsis.
J Community Hosp Intern Med Perspect
November 2024
UCI Medical Center, USA.
Most cases of Myxedema Coma are associated with primary hypothyroidism characterized by significantly elevated thyroid stimulating hormone (TSH) levels. However, this case presents an atypical manifestation of myxedema coma with low TSH levels despite severe hypothyroidism. The rarity of this presentation lies in the absence of central lesions typically responsible for such TSH suppression.
View Article and Find Full Text PDFA disturbed communication between hypothalamic-pituitary-ovary axis and gut microbiota in female infertility: is diet to blame?
J Transl Med
January 2025
Outpatient Clinic, Al Luqta Street, PO Box 26999, Doha, Qatar.
Female infertility is a multifactorial condition influenced by various genetic, environmental, and lifestyle factors. Recent research has investigated the significant impact of gut microbiome dysbiosis on systemic inflammation, metabolic dysfunction, and hormonal imbalances, which can potentially impair fertility. The gut-brain axis, a bidirectional communication system between the gut and the brain, also plays a significant role in regulating reproductive functions.
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