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Background: Antibody-drug conjugate (ADC) is an anticancer drug that links toxins to specifically targeted antibodies via linkers, offering the advantages of high target specificity and high cytotoxicity. However, complexity of its structural composition poses a greater difficulty for drug design studies.
Objectives: Pharmacokinetic/pharmacodynamic (PK/PD) based consideration of ADCs has increasingly become a hot research topic for optimal drug design in recent years, providing possible ideas for obtaining ADCs with desirable properties.
The application of multidisciplinary team combined flipped classroom teaching model in oral general course for clinical undergraduates.
BMC Med Educ
January 2025
School of Dentistry, Hainan Medical University, Haikou, 571199, PR China.
Background: Oral general course (OGC) is a basic subject of medical education. The implementation of multidisciplinary team (MDT) meets the individual needs of patients. Based on the concept of MDT, this study combined the theory and practice of flipped classroom teaching method to evaluate the teaching effect, so as to provide a basis and reference for the thinking transformation of medical students to clinicians.
View Article and Find Full Text PDFSynthetic Bilirubin-Based Nanomedicine Protects Against Renal Ischemia/Reperfusion Injury Through Antioxidant and Immune-Modulating Activity.
Adv Healthc Mater
January 2025
Department of Biological Sciences, KAIST Institute for the BioCentury, Center for Precision Bio-Nanomedicine, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Renal ischemia/reperfusion injury (IRI) is a common form of acute kidney injury. The basic mechanism underlying renal IRI is acute inflammation, where oxidative stress plays an important role. Although bilirubin exhibits potent reactive oxygen species (ROS)-scavenging properties, its clinical application is hindered by problems associated with solubility, stability, and toxicity.
View Article and Find Full Text PDFConcept-formation and deep disagreements in theoretical and practical reasoning.
Synthese
January 2025
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, OX3 7JX UK.
This paper explores the idea that deep disagreements essentially involve disputes about what counts as good reasoning, whether it is theoretical or practical reasoning. My central claim is that deep disagreements involve radically different paradigms of some principle or notion that is constitutively basic to reasoning-I refer to these as "basic concepts". To defend this claim, I show how we can understand deep disagreements by accepting the indeterminacy of concept-formation: concepts are not set in stone but are responsive to human needs, and differences in individuating and ordering concepts lead to clashes in paradigms of reasoning.
View Article and Find Full Text PDFThe Development and Feasibility Testing of the Nurse-Led Transitioning Adolescents Off Cancer Treatment (TACT) Intervention.
J Adv Nurs
January 2025
Department of Behavioural Medicine, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway.
Aim: To develop and assess the feasibility of a nurse-led intervention aimed at improving the transition from cancer treatment to survivorship for adolescents by providing personalised information and psychosocial and self-management support.
Design: Intervention development through co-creation with adolescent patients with cancer, their parents and health care professionals, based on the MRC framework and qualitative feasibility testing.
Methods: The intervention development involved three steps: (a) identifying the problem through interviews with key stakeholders and by reviewing existing evidence on transition tools and practices; (b) designing the intervention through co-creation workshops with stakeholders and (c) assessing feasibility, acceptability and participants' experiences of the intervention through interviews with adolescents, parents, healthcare professionals and teachers.
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