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Single-cell atlas reveals multi-faced responses of losartan on tubular mitochondria in diabetic kidney disease.
J Transl Med
January 2025
Department of Endocrine Medicine, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201306, Chin, China.
Background And Objective: Mitochondria are crucial to the function of renal tubular cells, and their dynamic perturbation in many aspects is an important mechanism of diabetic kidney disease (DKD). Single-nucleus RNA sequencing (snRNA-seq) technology is a high-throughput sequencing analysis technique for RNA at the level of a single cell nucleus. Here, our DKD mouse kidney single-cell RNA sequencing conveys a more comprehensive mitochondrial profile, which helps us further understand the therapeutic response of this unique organelle family to drugs.
View Article and Find Full Text PDFAlternative Splicing Events and Differently Expressed Genes During Peak Mortality in Large Yellow Croaker (Larimichthys crocea) Infected with Scuticociliate.
Mar Biotechnol (NY)
January 2025
Key Laboratory of Healthy Mariculture for the East China Sea, Ministry of Agriculture and Rural Affairs, Jimei University, Xiamen, China.
Large yellow croaker (Larimichthys crocea) is facing various threats from bacterial, viral, and parasitic diseases, especially scuticociliate. Scuticociliate is a facultative parasite causing high mortality in various marine fishes. In this study, an artificial scuticociliate infection model was successfully established for large yellow croaker.
View Article and Find Full Text PDFDifferential regulation of the "phytoglobin-nitric oxide respiration" in Medicago truncatula roots and nodules submitted to flooding.
Plant Sci
January 2025
UMR INRAE 1355, Université Nice Côte d'Azur, Institut Sophia Agrobiotech, 06903 Sophia Antipolis, France. Electronic address:
Flooding induces hypoxia in plant tissues, impacting various physiological and biochemical processes. This study investigates the adaptive response of the roots and nitrogen-fixing nodules of Medicago truncatula in symbiosis with Sinorhizobium meliloti under short-term hypoxia caused by flooding. Four-week-old plants were subjected to flooding for 1 to 4 days.
View Article and Find Full Text PDFThe Interplay between Metabolic Reprogramming, Mitochondrial Impairment, and Steroid Response in Proliferative Vitreoretinopathy.
Free Radic Biol Med
January 2025
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, P. R. China, No.251 Fu Kang Road, Nankai District, Tianjin 300384, P. R. China. Electronic address:
Proliferative vitreoretinopathy (PVR) is a major cause of rhegmatogenous retinal detachment repair failure. Despite many attempts to find therapeutics for PVR, no pharmacotherapy has been proven effective. Steroids, as the epitome, show uncertain clinical effectiveness, which lacks an explanation and hints at unappreciated mechanisms of PVR.
View Article and Find Full Text PDFLeaf Photosynthetic and Respiratory Thermal Acclimation in Terrestrial Plants in Response to Warming: A Global Synthesis.
Glob Chang Biol
January 2025
Key Laboratory of National Forestry and Grassland Administration on Forest Ecosystem Protection and Restoration of Poyang Lake Watershed, College of Forestry, Jiangxi Agricultural University, Nanchang, China.
Leaf photosynthesis and respiration are two of the largest carbon fluxes between the atmosphere and biosphere. Although experiments examining the warming effects on photosynthetic and respiratory thermal acclimation have been widely conducted, the sensitivity of various ecosystem and vegetation types to warming remains uncertain. Here we conducted a meta-analysis on experimental observations of thermal acclimation worldwide.
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