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Event-related theta synchronization over sensorimotor areas differs between younger and older adults and is related to bimanual motor control.
Neuroimage
January 2025
Movement & Neuroscience, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
When engaged in dynamic or continuous movements, action initiation involves modifying an ongoing motor program rather than initiating it from rest. Event-related theta synchronization over sensorimotor areas is a neurophysiological marker for modifying motor programs. We used electroencephalography (EEG) to examine how task complexity and age affect event-related synchronization (ERS) in the theta band during a dynamic bimanual, visuomotor pinch force task.
View Article and Find Full Text PDFNutrient control of splice site selection contributes to methionine addiction of cancer.
Mol Metab
January 2025
Department of Biological Chemistry, University of California, Irvine School of Medicine. Electronic address:
Objectives: Many cancer cells depend on exogenous methionine for proliferation, whereas non-tumorigenic cells can divide in media supplemented with the metabolic precursor homocysteine. This phenomenon is known as methionine dependence of cancer or methionine addiction. The underlying mechanisms driving this cancer-specific metabolic addiction are poorly understood.
View Article and Find Full Text PDFMapping the aging brain: Insights into microstructural changes from free water-corrected fractional anisotropy.
Neurosci Lett
January 2025
Department of Kinesiology and Applied Physiology, University of Delaware Newark DE USA. Electronic address:
Aging has a significant impact on brain structure, demonstrated by numerous MRI studies using diffusion tensor imaging (DTI). While these studies reveal changes in fractional anisotropy (FA) across different brain regions, they tend to focus on white matter tracts and cognitive regions, often overlooking gray matter and motor areas. Additionally, traditional DTI metrics can be affected by partial volume effects.
View Article and Find Full Text PDFLocal cortical structure pattern and genetic links in schizophrenia: An MRI and CRISPR/Cas9 study.
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Institute of Brain Science, National Yang-Ming Chiao Tung University, Taipei 11221, Taiwan; Brain Research Center, National Yang-Ming Chiao Tung University, Taipei 11221, Taiwan; Digital Medicine and Smart Healthcare Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan. Electronic address:
While the etiology of schizophrenia (SZ) remains elusive, its diverse phenotypes suggest the involvement of distinct functional cortical areas, and the heritability of SZ implies the underlying genetic factors. This study aimed to integrate imaging and molecular analyses to elucidate the genetic underpinnings of SZ. We investigated the local cortical structural pattern changes in Brodmann areas (BAs) by calculating the cortical structural pattern index (SPI) using magnetic resonance imaging analysis from 194 individuals with SZ and 330 controls.
View Article and Find Full Text PDFEstimation of the effects of hand growth on muscle activation patterns: A musculoskeletal modeling study.
J Biomech
January 2025
The Joint Department of Biomedical Engineering, the University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; North Carolina State University, Raleigh, NC, United States.
Throughout childhood growth and development, both the nervous and the musculoskeletal systems undergo rapid change. The goal of this study was to examine the impact of growth-related changes in skeletal size and muscle strength on the neural control of finger force generation. By modifying an existing OpenSim hand model in accordance with pediatric anthropometric data, we created 10 distinct models representing males and females at each year of development from 6 to 10 years old.
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