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Assessment of stigma among patients living with Parkinson's disease: an exploratory study.
Acta Neurol Belg
January 2025
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
Objective: This cross-sectional study aims to assess the levels of stigma among patients with Parkinson's disease (PD) and identify the demographic and clinical factors influencing both internal and external stigma.
Materials And Methods: A total of 200 patients diagnosed with PD were recruited from Beijing Tiantan Hospital between June 2023 and June 2024 using convenience sampling. Data were collected through face-to-face interviews, including demographic information, disease severity assessed via the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), and stigma levels measured using the 24-item Stigma Scale for Chronic Illness (SSCI).
A low-cost printed circuit board-based centrifugal microfluidic platform for dielectrophoresis.
Microsyst Nanoeng
January 2025
Henry Samueli School of Engineering, University of California, Irvine, CA, USA.
In recent decades, electrokinetic handling of microparticles and biological cells found many applications ranging from biomedical diagnostics to microscale assembly. The integration of electrokinetic handling such as dielectrophoresis (DEP) greatly benefits microfluidic point-of-care systems as many modern assays require cell handling. Compared to traditional pump-driven microfluidics, typically used for DEP applications, centrifugal CD microfluidics provides the ability to consolidate various liquid handling tasks in self-contained discs under the control of a single motor.
View Article and Find Full Text PDFIntestinal microbiota distribution and changes in different stages of Parkinson's disease: A meta-analysis, bioinformatics analysis and in vivo simulation.
Biosci Trends
January 2025
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.
Parkinson's disease (PD) is a progressive disease that requires effective staging management. The role of intestinal microbiota in PD has been studied, but its changes at different stages are not clear. In this study, meta- analysis, bioinformatics analysis and in vivo simulation were used to explore the intestinal microbiota distribution of PD patients and models at different stages.
View Article and Find Full Text PDFUnraveling the dual role of bilirubin in neurological Diseases: A Comprehensive exploration of its neuroprotective and neurotoxic effects.
Brain Res
January 2025
Neuropharmacology Division, Department of Pharmacology, ISF College of Pharmacy, Moga 142001, Punjab, India. Electronic address:
Neurodegenerative disorders are characterized by a progressive loss of neurons, causing substantial deficits in motor and cognitive functioning. Bilirubin is a yellow by-product of heme, existing in two primary isoforms namely unconjugated and conjugated, while initially produced unconjugated isomer is lipophilic and cytotoxic in nature. At physiological levels, bilirubin has an important role in brain function by acting as a powerful antioxidant, preventing brain tissues from oxidative damage by eliminating reactive oxygen species (ROS).
View Article and Find Full Text PDFEarly-Life Antibiotic Exposures: Paving the Pathway for Dysbiosis-Induced Disorders.
Eur J Pharmacol
January 2025
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Gelugor, 11800, Penang, Malaysia. Electronic address:
Microbiota encompasses a diverse array of microorganisms inhabiting specific ecological niches. Gut microbiota significantly influences physiological processes, including gastrointestinal motor function, neuroendocrine signalling, and immune regulation. They play a crucial role in modulating the central nervous system and bolstering body defence mechanisms by influencing the proliferation and differentiation of innate and adaptive immune cells.
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