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Amelioration and Immuno-modulation by Ashwagandha on Wi-fi Induced Oxidative Stress in Regulating Reproduction Via Estrogen Receptor Alpha in Male Japanese Quail.
Reprod Sci
January 2025
Department of Zoology, Faculty of Science, University of Allahabad, Prayagraj, 211002, UP, India.
As global change threatens avian biodiversity, understanding species responses to environmental perturbations due to radiation emitted by enormous increase in the application of wireless communication is very urgent. The study investigates the effect of MW radiation on redox balance, stress level, male fertility and the efficacy of Withania somnifera (WS) root extract (100 mg/kg body weight) orally administered in 8 weeks old mature male Japanese quail exposed to 2.4 GHz MW radiation for 2 h/day for 30 days with power density = 0.
View Article and Find Full Text PDFPreclinical pharmacokinetics, absolute bioavailability and dose proportionality evaluation of bioactive phytochemical Withanone in rats.
Bioorg Chem
January 2025
Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, United Kingdom. Electronic address:
Withanone (WN), a bioactive phytochemical isolated from the medicinal herb Withania somnifera, has shown multiple pharmacological and therapeutic successes, including neuroprotective and anti-cancer activities. However, detailed pharmacokinetic (PK) properties of pure WN were not well defined. Pharmacokinetic (PK) characteristics, dose proportionality, and absolute bioavailability of pure WN were explored in rats using an efficient, reliable, and sensitive LC-MS/MS assay to address this gap.
View Article and Find Full Text PDFHarnessing the immunomodulatory potential of ashwagandha (Withania somnifera) against epizootic ulcerative syndrome: a sustainable approach for hill aquaculture.
Dis Aquat Organ
January 2025
ICAR Research Complex for NEH Region, Umiam, Meghalaya PIN-793103, India.
The present study evaluated the immunomodulatory and disease resistance-enhancing effects of dietary supplementation of Withania somnifera root powder in Labeo rohita (22.10 ± 3.30 g, 12.
View Article and Find Full Text PDFPharmacological profiling of medicinal plants: a contemporary overview.
Nat Prod Res
January 2025
Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad, Pakistan.
Throughout history, medicinal plants have played a significant role in various traditional medical systems. This review article focusses on therapeutic properties of , and . These plants have earned recognition for their curative, medical, life-sustaining and chemical uses.
View Article and Find Full Text PDFEvaluation of the Anxiolytic and Antidepressant Effects of Standardized Ashwagandha () Root Extract in Wistar Rats.
Prev Nutr Food Sci
December 2024
Food Science R&D Center, Kolmar BNH, Seoul 06800, Korea.
Ashwagandha () is a popular herb in Ayurveda, the traditional medicine system in India. It is known to exert stress-mitigating properties and has been extensively studied for its safety and efficacy in various disorders. This study assessed the effects of Ashwagandha root extract (ARE) on stress in rats.
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