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Electroacupuncture improves cognitive impairment after subarachnoid hemorrhage in rats through the PI3K/AKT signaling pathway.
Acupunct Med
January 2025
Combination of Acupuncture and Medicine Innovation Research Center, Shaanxi University of Chinese Medicine, Xianyang, China.
Objective: Cognitive impairment (CI) is highly prevalent in subarachnoid hemorrhage (SAH) patients. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway plays a critical role in neuronal survival in a variety of central nervous system injuries. This study aimed to determine whether electroacupuncture (EA) at and LI20 ameliorates SAH-CI in a rat model and to examine whether it modulates the PI3K/AKT pathway by administering a PI3K inhibitor (LY294002) versus dimethyl sulfoxide (DMSO) vehicle.
View Article and Find Full Text PDFNanoporous high-entropy alloys and metallic glasses: advanced electrocatalytic materials for electrochemical water splitting.
Chem Commun (Camb)
January 2025
Tianjin Key Laboratory of Advanced Functional Porous Materials, Institute for New Energy Materials and Low-Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China.
Electrochemical water splitting is a promising approach to convert renewable energy into hydrogen energy and is beneficial for alleviating environmental pollution and energy crises, and is considered a clean method to achieve dual-carbon goals. Electrocatalysts can effectively reduce the reaction energy barrier and improve reaction efficiency. However, designing electrocatalysts with high activity and stability still faces significant challenges, which are closely related to the structure and electronic configuration of catalysts.
View Article and Find Full Text PDFRepresentative modeling of biocompatible MXene nanocomposites for next-generation biomedical technologies and healthcare.
J Mater Chem B
January 2025
Department of Advanced Materials Science & Engineering, Hanseo University, Seosan, Chungnam 31962, Republic of Korea.
MXenes are a class of 2D transition metal carbides and nitrides (MXT) that have attracted significant interest owing to their remarkable potential in various fields. The unique combination of their excellent electromagnetic, optical, mechanical, and physical properties have extended their applications to the biological realm as well. In particular, their ultra-thin layered structure holds specific promise for diverse biomedical applications.
View Article and Find Full Text PDFChallenges for switching central nervous system and psychiatric medication products: A review of the literature.
J Psychopharmacol
January 2025
Department of Psychiatry, McGill University, Montreal, QC, Canada.
Background: Switching between versions of medication products happens commonly despite challenges in achieving bioequivalence and therapeutic equivalence. Central nervous system and psychiatric drugs, especially those that are technically demanding to manufacture and have complex pharmacokinetic properties, such as long-acting injectables (LAIs), pose particular challenges to bioequivalence and safe and efficacious drug switching.
Aims: To assess whether drugs deemed "bioequivalent" are truly interchangeable in drug switching.
Non-Newtonian lacuno-canalicular fluid flow in bone altered by mechanical loading and magnetic field.
Comput Methods Biomech Biomed Engin
January 2025
Department of Mathematics, National Institute of Technology Uttarakhand, Srinagar, India.
As humans age, they experience deformity and a decrease in their bone strength, such brittleness in the bones ultimately lead to bone fracture. Magnetic field exposure combined with physical exercise may be useful in mitigating age-related bone loss by improving the canalicular fluid motion within the bone's lacuno-canalicular system (LCS). Nevertheless, an adequate amount of fluid induced shear stress is necessary for the bone mechano-transduction and solute transport in the case of brittle bone diseases.
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