Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0024-3205(65)90216-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Palmitic Acid in the Diet of Dairy Goats and Its Effect on Physicochemical Characteristics and Fatty Acid Profile of Goat Kid Meat.
Anim Sci J
January 2025
General Terán Experimental Field, National Institute of Forestry, Agricultural and Livestock Research, General Terán, Mexico.
The objective of this study was to evaluate the impact of incorporating palmitic acid into the diet of dairy goats on the physicochemical characteristics, nutritional value, and fatty acid profile of goat kid meat. For this, 28 Creole local kids were used, divided into the following treatments: grazing, kids fed milk from grazing goats; base diet, kids fed milk from goats in confinement with a total mixed ration; base diet + 3PA, kids fed milk from goats in confinement that consumed the base diet plus 3% palmitic acid; and base diet + 6PA, kids fed milk from goats in confinement fed with the base diet plus 6% palmitic acid. The feeding period was conducted over a 30-day period.
View Article and Find Full Text PDFCryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT.
Nat Commun
January 2025
Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK.
Conjugation plays a major role in dissemination of antimicrobial resistance genes. Following transfer of IncF-like plasmids, recipients become refractory to a second wave of conjugation with the same plasmid via entry (TraS) and surface (TraT) exclusion mechanisms. Here, we show that TraT from the pKpQIL and F plasmids (TraT and TraT) exhibits plasmid surface exclusion specificity.
View Article and Find Full Text PDFRoles of acyl carrier proteins in ladderane fatty acid producing-organisms.
Biochim Biophys Acta Gen Subj
January 2025
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Jahnstrasse 29, D-69120 Heidelberg, Germany. Electronic address:
Ladderanes are highly strained hydrocarbons consisting of two or more linearly concatenated cyclobutane rings. Strikingly, ladderane moieties are part of unique fatty acids and fatty alcohols that are exclusively found in the membrane lipids of anaerobic ammonium-oxidizing (anammox) bacteria. These bacteria express a distinctive gene cluster (cluster I) that has been suggested to be responsible for ladderane fatty acid (FA) biosynthesis in addition to a cluster likely involved in canonical FA biosynthesis (cluster III).
View Article and Find Full Text PDFTopical Delivery of Artificial Lipidated Antifungal Proteins for the Treatment of Subcutaneous Fungal Infections Using a Biocompatible Ionic Liquid-Based Microemulsion.
ACS Appl Mater Interfaces
January 2025
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Fukuoka 819-0395, Japan.
The rising incidence of fungal infections, compounded by the emergence of severe antifungal resistance, has resulted in an urgent need for innovative antifungal therapies. We developed an antifungal protein-based formulation as a topical antifungal agent by combining an artificial lipidated chitin-binding domain of antifungal chitinase (LysM-lipid) with recently developed ionic liquid-in-oil microemulsion formulations (MEFs). Our findings demonstrated that the lipid moieties attached to LysM and the MEFs effectively disrupted the integrity of the stratum corneum in a mouse skin model, thereby enhancing the skin permeability of the LysM-lipids.
View Article and Find Full Text PDFImmunometabolic reprogramming in macrophages infected with active and dormant : differential modulation of respiration, glycolysis, and fatty acid utilization.
Infect Immun
December 2024
Laboratory of Applied Immunology, Institute of Biology Sciences, University of Brasília, Brasília, Brazil.
Dormancy is an adaptation in which cells reduce their metabolism, transcription, and translation to stay alive under stressful conditions, preserving the capacity to reactivate once the environment reverts to favorable conditions. Dormancy and reactivation of () are closely linked to intracellular residency within macrophages. Our previous work showed that murine macrophages rely on the viable but not cultivable (VBNC-a dormancy phenotype) fungus from active , with striking differences in immunometabolic gene expression.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!