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Estimation of tuberculosis mortality burden in Spain: a review of the major data sources.
ERJ Open Res
March 2025
National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain.
Introduction: In Spain, notifications of cases of tuberculosis (TB) are registered through the National Epidemiological Surveillance Network (RENAVE). The Minimum Basic Data Set (CMBD) provides information on hospital discharge and the National Statistics Institute (INE) draws on medical death certificates. This study aimed to describe TB mortality in Spain and to compare estimates across data sources, as well as with EU/EEA countries.
View Article and Find Full Text PDFPharmacometabolomics in TB meningitis-Understanding the pharmacokinetic, metabolic, and immune factors associated with anti-TB drug concentrations in cerebrospinal fluid.
PLoS One
March 2025
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America.
Poor penetration of many anti-tuberculosis (TB) antibiotics into the central nervous system (CNS) is thought to be a major driver of morbidity and mortality in TB meningitis (TBM). While the amount of a particular drug that crosses into the cerebrospinal fluid (CSF) varies from person to person, little is known about the host factors associated with interindividual differences in CSF concentrations of anti-TB drugs. In patients diagnosed with TBM from the country of Georgia (n = 17), we investigate the association between CSF concentrations of anti-TB antibiotics and multiple host factors including serum drug concentrations and CSF concentrations of metabolites and cytokines.
View Article and Find Full Text PDFProlonged Corticosteroid Use in the Treatment of Tuberculous Meningoencephalitis: A Case Report.
Medicina (Kaunas)
January 2025
Department of Infectology, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, Latvia.
Tuberculous meningoencephalitis is a rare manifestation of , with the most severe form and highest mortality. It can cause multiple complications, and treatment is difficult, as drugs cannot properly diffuse through the haemato-encephalitic barrier. We reported the case of a 17-year-old female patient who was admitted to the emergency room department with a fever for previous two weeks (up to 39 °C), dizziness, difficulty walking, and weight loss.
View Article and Find Full Text PDFCombined cerebrospinal fluid sCD163, MMP-9, with serum NCAM1 protein levels for predicting the prognosis of patients with tuberculous meningitis.
Sci Rep
February 2025
Department of Tuberculosis, Hunan Chest Hospital, 519 Xianjiahu Road, Yuelu District, Changsha, Hunan, 410000, China.
Tuberculous meningitis (TBM) is the most serious type of tuberculosis infection, and there is a lack of accurate diagnostic targets for TBM. Therefore, it is of great clinical and public health significance to find a specific target for early diagnosis and prediction of the prognosis of TBM. From January 2021 to February 2024, 110 TBM patients and 122 patients with non-tumor, non-infectious headaches were admitted to Hunan Chest Hospital.
View Article and Find Full Text PDFA Novel Diagnostic Prediction Model for Distinguishing Between Tuberculous and Cryptococcal Meningitis.
Clin Med Res
December 2024
Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China
Tuberculous meningitis (TBM) and cryptococcal meningitis (CM) are easily misdiagnosed due to atypical clinical symptoms. It is difficult for physcians to achieve a rapid and accurate differential diagnosis of TBM in the early stages of disease onset. The aim of this study was to construct a diagnostic prediction model for TBM and CM.
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