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A Reusable Capillary Flow-Driven Microfluidic System for Abscisic Acid Detection Using a Competitive Immunoassay.
Sensors (Basel)
January 2025
Instituto de Engenharia de Sistemas e Computadores-Microsistemas e Nanotecnologias (INESC-MN), Rua Alves Redol, 1000-029 Lisbon, Portugal.
Point-of-care (PoC) devices offer a promising solution for fast, portable, and easy-to-use diagnostics. These characteristics are particularly relevant in agrifood fields like viticulture where the early detection of plant stresses is crucial to crop yield. Microfluidics, with its low reagent volume requirements, is well-suited for such applications.
View Article and Find Full Text PDFOptimization and Validation of an Ultra-Performance Liquid Chromatography with Quadrupole Detector Mass Spectrometry Quantification Method for the Simultaneous Detection of Tazarotene and Tazarotenic Acid in Porcine Skin: An In Vitro Study.
Int J Mol Sci
January 2025
Faculty of Pharmaceutical Sciences, University of Iceland, 107 Reykjavik, Iceland.
Exploring tazarotene, a third-generation retinoid for potential hand osteoarthritis treatment, this study presents the development and validation of an ultra-performance liquid chromatography with quadrupole detector mass spectrometry (UPLC-QDa) method for the simultaneous quantification of tazarotene and tazarotenic acid, its active metabolite, in porcine skin. Method development involved a design-of-experiments approach for chromatographic optimization of gradient steepness, organic solvent volume, column temperature, capillary voltage, flow rate, and cone voltage. Central composite orthogonal design was used to optimize peak area, peak width, retention time, and resolution.
View Article and Find Full Text PDFA Window into the Vascular Endothelium in Covid-19: Nails.
Dermatol Pract Concept
January 2025
Pamukkale University Faculty of Medicine, Department of Dermatology, Denizli, Turkey.
Introduction: Endothelial damage is associated with acute and long-term coronavirus disease 2019 (COVID-19) complications. Proximal nailfold capillaries and nail beds give important clues to microvascular changes associated with endothelial dysfunction.
Objective: We aimed to use dermoscopy to examine the proximal nailfold capillaries and nail bed of COVID-19 patients and identify microvascular changes.
Thermally Conductive Shape-Stabilized Phase Change Materials Enabled by Paraffin Wax and Nanoporous Structural Expanded Graphite.
Nanomaterials (Basel)
January 2025
State Key Laboratory of Nonferrous Metals and Processes, GRIMN Group Co., Ltd., Beijing 100088, China.
Paraffin wax (PW) has significant potential for spacecraft thermal management, but low thermal conductivity and leakage issues make it no longer sufficient for the requirements of evolving spacecraft thermal control systems. Although free-state expanded graphite (EG) as a thermal conductivity enhancer can ameliorate the above problems, it remains challenging to achieve higher thermal conductivity (K) (>8 W/(m·K)) at filler contents below 10 wt.% and to mitigate the leakage problem.
View Article and Find Full Text PDFModeling Geobacillus stearothermophilus spores inactivation in plant-based drinks to design UHT processing.
Food Res Int
February 2025
Oniris VetAgroBio, INRAE, SECALIM, Nantes, France. Electronic address:
This study provides predictive models for G. stearothermophilus spores inactivation in four plant-based drinks, half-skimmed bovine milk and Brain Heart Infusion (BHI) broth and while also evaluating of matrix effect on inactivation. Heat inactivation was performed using the capillary tube method within the temperature range 115-127 °C.
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