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Background: Rifampicin is a strong inducer of the hepatic cytochrome P450 (CYP) family and is known to interact with many clinical drugs. However, to our knowledge, no case of worsening heart failure (HF) due to the interaction between rifampicin and HF drugs has been reported.

Case Summary: A 32-year-old female, who had undergone intracardiac repair for an incomplete atrioventricular septal defect with dextrocardia and prosthetic valve replacements for right and left atrioventricular valve regurgitation, presented as an outpatient.

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Rationale: Approximately one-fifth ischemic stroke are attributed to cardioembolism. Patients with cardioembolic stroke often develop a more severe disability and a higher risk of stroke recurrence. Cardiac myxoma, although uncommon, can serve as a potentially curable cause of acute embolic strokes.

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We describe a case of culture-negative right-sided endocarditis for which simultaneous transcatheter vegetectomy was performed with leadless pacemaker implantation and removal of a temporary externalized pacing system. The patient did not have a recurrence of endocarditis highlighting the safety and efficacy of same-procedure vegetation removal and pacemaker implantation. This report documents a novel approach for the treatment of cardiac implantable electronic device-associated endocarditis in poor surgical candidates who are pacemaker-dependent.

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How is ceftobiprole used in Canada: the CLEAR study final results.

Expert Rev Anti Infect Ther

August 2024

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

Article Synopsis
  • The study analyzes the clinical usage data of ceftobiprole in Canada, focusing on its effectiveness in treating severe infections, particularly those caused by MRSA, through the CLEAR registry.
  • Ceftobiprole is often prescribed for patients who do not respond to other antibiotics and is commonly used in combination with daptomycin and/or vancomycin, demonstrating high success rates and excellent safety.
  • Additionally, the drug is used empirically in certain cases of community-acquired and hospital-acquired bacterial pneumonia, reinforcing its utility in clinical settings.
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Infective endocarditis caused by : A case report and review of the literature.

IDCases

April 2024

Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

is a Gram-positive coccus that can be easily misidentified as spp. or streptococci. Infection with is associated with the consumption of raw fish and unpasteurized dairy products.

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