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Virtual screening: hope, hype, and the fine line in between.
Expert Opin Drug Discov
January 2025
Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, NY, USA.
Introduction: Technological advancements in virtual screening (VS) have rapidly accelerated its application in drug discovery, as reflected by the exponential growth in VS-related publications. However, a significant gap remains between the volume of computational predictions and their experimental validation. This discrepancy has led to a rise in the number of unverified 'claimed' hits which impedes the drug discovery efforts.
View Article and Find Full Text PDFBibliometric analysis of global research trends in vestibular neuritis (1980-2024).
Eur Arch Otorhinolaryngol
January 2025
Faculty of Applied Sciences, Department of Accounting and Financial Management, Necmettin Erbakan University, Konya, Turkey.
Purpose: Vestibular neuritis (VN) is a common cause of vertigo with significant impact on patients' quality of life. This study aimed to analyze global research trends in VN using bibliometric methods to identify key themes, influential authors, institutions, and countries contributing to the field.
Methods: We conducted a comprehensive search of the Web of Science Core Collection database for publications related to VN from 1980 to 2024.
Volume-viscosity swallow test to facilitate individualized dietary modifications for dysphagia following intracerebral hemorrhage.
Eur Arch Otorhinolaryngol
January 2025
Geriatric Care Research Center, Xiamen Medical College, Xiamen, Fujian, 361023, China.
Purpose: This study examined the effects of individualized dietary modifications based on the volume-viscosity swallow test (V-VST) on functional oral intake, incidence of pneumonia, and swallowing-related quality of life in individuals with intracerebral hemorrhage.
Methods: One hundred and seven participants with signs of dysphagia in the acute and early subacute phases of stroke following intracerebral hemorrhage were randomly assigned into an experimental group for individualized dietary modifications based on V-VST plus routine standard care (n = 53), and a control group for routine care alone (n = 54). Incidence of pneumonia, functional oral intake scale (FOIS) ratings and Eating Assessment Tool (EAT-10) scores before and after intervention were evaluated.
Total population for a resource-limited single consumer model.
J Math Biol
January 2025
Department of Integrative Biology, Oklahoma State University, Stillwater, OK, 74078, USA.
In the past several decades, much attention has been focused on the effects of dispersal on total populations of species. In Zhang (EL 20:1118-1128, 2017), a rigorous biological experiment was performed to confirm the mathematical conclusion: Dispersal tends to enhance populations under a suitable hypothesis. In addition, mathematical models keeping track of resource dynamics in population growth were also proposed in Zhang (EL 20:1118-1128, 2017) to understand this remarkable phenomenon.
View Article and Find Full Text PDFFerroptosis triggers mitochondrial fragmentation via Drp1 activation.
Cell Death Dis
January 2025
CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.
Constitutive mitochondrial dynamics ensure quality control and metabolic fitness of cells, and their dysregulation has been implicated in various human diseases. The large GTPase Dynamin-related protein 1 (Drp1) is intimately involved in mediating constitutive mitochondrial fission and has been implicated in mitochondrial cell death pathways. During ferroptosis, a recently identified type of regulated necrosis driven by excessive lipid peroxidation, mitochondrial fragmentation has been observed.
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