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Coexistence of Graves' disease with acute rheumatic fever treated as thyroid storm in young Thai patient.
J Pediatr Endocrinol Metab
June 2023
Division of Endocrinology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Article Synopsis
- A case study involves an 8-year-old girl who developed chorea (involuntary movements) alongside symptoms of Graves' disease and acute rheumatic fever.
- The child exhibited several symptoms over a couple of months, including involuntary movements, fever, rapid heartbeat, and thyroid enlargement, initially suggesting a thyroid storm, which was treated with various medications.
- The report emphasizes the importance of recognizing underlying cardiac issues when symptoms like chorea and congestive heart failure occur in patients with Graves' disease.
Thyrotoxicosis in a Postpartum Adolescent: A Simulation Case for Emergency Medicine Providers.
MedEdPORTAL
September 2020
Assistant Professor, Departments of Emergency Medicine and Pediatrics, Division of Pediatric Emergency Medicine, Warren Alpert Medical School of Brown University and Rhode Island Hospital/Hasbro Children's Hospital; Director of Pediatric Simulation, Lifespan Medical Simulation Center.
Introduction: Thyroid storm is a rare but life-threatening disease process that may be difficult to recognize and mimics other disease processes. It is critical for the emergency medicine clinician to be able to recognize thyroid storm in patients in order to effectively stabilize and treat them.
Methods: In this standardized patient case, learners were faced with a 17-year-old postpartum woman presenting to the emergency department with respiratory distress and altered mental status secondary to thyroid storm.
New variant (Val597Ile) in transmembrane region of the TSH receptor with human chorionic gonadotropin hypersensitivity in familial gestational hyperthyroidism.
Clin Endocrinol (Oxf)
September 2020
Biochemistry and Genetic Laboratory, Federative Institute of Biology, CHU Toulouse, Toulouse, France.
Objectives: Only two mutations at the lysine 183 amino acid in the extracellular N-terminal domain of human TSH receptor (hTSHR) have been associated with hypersensitivity to hCG and familial gestational hyperthyroidism.
Design: Describe a new variant of the TSHR gene with hCG hypersensitivity found in two women of the same family diagnosed with gestational hyperthyroidism.
Patients: A 38-year-old woman was seen during the first trimester of her second pregnancy for thyrotoxicosis with increased fT3 and fT4 concentrations and low TSH levels without anti-TSH receptor antibody.
Environmental exposure to pesticides and risk of thyroid diseases.
Toxicol Lett
October 2019
University of Almería School of Health Sciences, Almería, Spain.
Occupational and environmental exposure to pesticides has been associated with thyroid dysfunction, particularly changes in circulating thyroid hormone levels (T3, T4) and thyroid stimulating hormone (TSH). This study assessed the association between environmental exposure to pesticides and the risk of developing thyroid diseases. A population-based case-control study was carried out among Spanish populations living in areas categorized as of high or low pesticide use according to agronomic criteria, which were used as surrogates for environmental exposure to pesticides.
View Article and Find Full Text PDFOrgan Dose Estimates for Hyperthyroid Patients Treated with (131)I: An Update of the Thyrotoxicosis Follow-Up Study.
Radiat Res
December 2015
a Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892;
The Thyrotoxicosis Therapy Follow-up Study (TTFUS) is comprised of 35,593 hyperthyroid patients treated from the mid-1940s through the mid-1960s. One objective of the TTFUS was to evaluate the long-term effects of high-dose iodine-131 ((131)I) treatment (1-4). In the TTFUS cohort, 23,020 patients were treated with (131)I, including 21,536 patients with Graves disease (GD), 1,203 patients with toxic nodular goiter (TNG) and 281 patients with unknown disease.
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