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Topical Formulation Comprising Fatty Acid Extract from Cod Liver Oil: Development, Evaluation and Stability Studies.
Mar Drugs
June 2016
Lipid Pharmaceuticals, Grandagardur 16, 101 Reykjavik, Iceland.
The purpose of this study was to develop a pharmaceutical formulation containing fatty acid extract rich in free omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid for topical use. Although the health benefits of cod liver oil and other fish oils taken orally as a dietary supplement have been acknowledged and exploited, it is clear that their use can be extended further to cover their antibacterial properties. In vitro evaluation showed that 20% (v/v) fatty acid extract exhibits good activity against strains of the Gram-positive bacteria Staphylococcus aureus, Enterococcus faecalis, Streptoccoccus pyogenes and Streptoccoccus pneumonia.
View Article and Find Full Text PDFAn evaluation of the effect of differing lengths of spa therapy upon patients with osteoarthritis (OA).
Complement Ther Clin Pract
February 2008
Health Resort Laboratory, Pärnu College, University of Tartu, Ringi 35, Pärnu 80010, Estonia.
The use of spa therapy in Estonia commonly consists of courses up to 3-4 weeks in duration for the management of rheumatic diseases. This study sought to evaluate whether there was any difference in the alleviation of patients symptoms between 6 and 12 day courses of spa therapy in the management of osteoarthritis (OA). A total of 296 patients participated in the research.
View Article and Find Full Text PDFIsolated and complex effects of environmental factors on adaptation abilities of the body, function of different organs and systems, composition of peripheral blood and course of disease were studies in 245 children aging from 6 to 14 years with remitted chronic pyelonephritis with normal renal function. Mineral water "Naftusia" (100-200 ml a day), lumbar applications of ozocerite, mineral baths and exercise therapy were used. Our findings give a reason to consider sanatory rehabilitation a promising method of health promotion and correction of functional disorders.
View Article and Find Full Text PDFDevelopment and evaluation of sustained-release ibuprofen-wax microspheres. I. Effect of formulation variables on physical characteristics.
Pharm Res
November 1991
Department of Pharmaceutical Chemistry and Pharmaceutics, School of Pharmacy, Duquesne University, Pittsburgh, Pennsylvania 15282.
A congealable disperse phase encapsulation method was used to prepare sustained-release ibuprofen-wax microspheres. Microspheres prepared with paraffin wax, such as ceresine and microcrystalline waxes, using polyvinylpyrrolidone (PVP) as dispersant had a tendency to aggregate, but the addition of wax modifiers (stearyl alcohol and glyceryl monostearate) greatly reduced aggregation. Optimum modifier and dispersant concentrations were 20% (w/w) and 5% (w/v), respectively.
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