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[Psychological aspects in occupational dermatology].
Dermatologie (Heidelb)
January 2025
Sektion Berufsdermatologie, Zentrum Hautklinik, Universitätsklinikum Heidelberg, Ruprecht-Karls-Universität Heidelberg, Voßstr. 2, 69115, Heidelberg, Deutschland.
The prevalence of psychological disorders in the general population and, therefore, in dermatological and allergological patients continues to increase. Psychodermatology as a branch of dermatology is also becoming ever more relevant in occupational dermatology. Psychological comorbidities and cofactors like depression and anxiety disorders or stress are increasingly important, which must be considered regarding diagnostics and therapy selection.
View Article and Find Full Text PDFIncreasing dosing intervals for biologics in atopic dermatitis-why, who, when and how?
J Eur Acad Dermatol Venereol
January 2025
Department of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.
Biologics approved and in development for atopic dermatitis offer life-changing clinical efficacy with a relatively banal long-term safety profile requiring no laboratory monitoring. Biologic therapies also have their drawbacks, including high payor cost and the need to be administered as every other week subcutaneous injections. Addressing these concerns, studies of longer dosing intervals have been performed in the formal clinical trial setting and during real-world clinical care.
View Article and Find Full Text PDFSex hormones and allergies: exploring the gender differences in immune responses.
Front Allergy
January 2025
Research Institute of Biomedical Sciences, University Center of Health Sciences, University of Guadalajara, Guadalajara, Mexico.
Allergies are closely associated with sex-related hormonal variations that influence immune function, leading to distinct symptom profiles. Similar sex-based differences are observed in other immune disorders, such as autoimmune diseases. In allergies, women exhibit a higher prevalence of atopic conditions, such as allergic asthma and eczema, in comparison to men.
View Article and Find Full Text PDFArea-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis.
Dermatol Res Pract
January 2025
The Institute for Environmental Health and Safety, Seokyeong University, Seoul, Republic of Korea.
SCORring atopic dermatitis (SCORAD) is widely used to assess the severity of atopic eczema, but score systems based on the entire body may be limited in effective monitoring and intervention. It is crucial to monitor moisture levels in each affected body part, but empirical research is still lacking. The objective of this study was to analyze the levels of stratum corneum hydration (SCH) and transepidermal water loss (TEWL) in atopic dermatitis (AD) patients, focusing on the presence and location of atopic lesions at different body sites.
View Article and Find Full Text PDFDesign, Preparation, and Ex Vivo Skin Permeation of Doxepin Microemulsion System for Topical Delivery.
J Cosmet Dermatol
January 2025
Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Background: Doxepin (DX) is used orally to relieve itching but can cause side effects like blurred vision, dry mouth, and drowsiness due to its antimuscarinic effect. To reduce these adverse effects and improve skin permeation, DX is being developed in topical formulations. This study aims to improve DX skin absorption by developing a microemulsion (ME) formulation (ME-DX).
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