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Natural Products Analysis Through Time: From Past Achievements to Future Prospects.
Methods Mol Biol
January 2025
Natural Products Lab, Institute of Biology, Leiden University, Leiden, The Netherlands.
This introductory chapter traces the evolution of (bio)chemical assays, emphasizing the critical role of robust protocols in ensuring reproducibility-a fundamental aspect of scientific research. With the advent of systems biology, the need for standardized methods has intensified, particularly for integrating vast datasets in open-access formats. The historical progression from basic plant morphology to advanced chromatographic and spectroscopic techniques in phytochemistry highlights the necessity for precise, reproducible protocols.
View Article and Find Full Text PDFUltrasensitive Flexible NO Sensors with Remote-Controllable ADC-Electropolymerized Conducting Polymers on Plastic.
ACS Nano
January 2025
SKKU Advanced Institute of Nanotechnology (SAINT) and Department of Nano Science and Technology, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Alternating- and direct-current (ADC) bipolar electropolymerization (EP) offers an efficient and scalable approach for the lateral synthesis of conjugated macromolecules, enabling the simultaneous polymerization and deposition of large conducting polymer films with intriguing fractal-like ramified topographies onto arbitrary insulating substrates under remote control. In this study, we presented the remote synthesis of poly(3,4-ethylenedioxythiophene) (PEDOT):anion sensing films on a plastic substrate, aimed at their use in flexible nitrogen dioxide (NO) gas sensors. Notably, the PEDOT:ClO films exhibited excellent gas-sensing characteristics, with a sensitivity of 54.
View Article and Find Full Text PDFUnraveling the catalase dynamics: Biophysical and computational insights into co-solutes driven stabilization under extreme pH conditions.
Int J Biol Macromol
January 2025
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address:
Catalase plays a vital role in eliminating toxic peroxides from the human body and the environment. The versatile applications of this enzyme extend across biotechnological industries and innovative bioremediation approaches. Nonetheless, ensuring enzyme stability is a challenging task.
View Article and Find Full Text PDFSpectroscopic and in silico data indicate that phenolic acids interact with aldose reductase with different degrees of affinity at a single binding site.
Int J Biol Macromol
January 2025
INBIAS-CONICET, Departamento de Biología Molecular, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, Río Cuarto, 5800 Córdoba, Argentina. Electronic address:
Our previous studies demonstrated that the enzyme aldose reductase (AR) is activated by its interaction with tubulin, a mechanism which can lead to the emergence of secondary diseases in diabetic patients. We also found that different compounds derived from phenolic acid (CAFs) can prevent this interaction and thus AR activation. Here, we used spectroscopic and bioinformatic techniques to explore the interaction between AR and three CAFs: 3-nitrotyrosine (NTyr), Tyrosine (Tyr), and vanillic acid (Van).
View Article and Find Full Text PDFDecoding the excited-state dynamics of carbonyl-containing carotenoids: Insights from the Ind series.
Biochim Biophys Acta Mol Cell Biol Lipids
January 2025
Department of Applied Chemistry for Environment, School of Biological and Environmental Sciences, Kwansei Gakuin University, 1 Gakuen-Uegahara, Sanda, Hyogo 669-1330, Japan.
Carotenoids are naturally occurring pigments essential for both light-harvesting and photoprotection in photosynthetic processes. Among these, carbonyl-containing carotenoids exhibit distinctive excited state properties due to the presence of intramolecular charge transfer (ICT) in their excited states. In this study, we synthesized a novel family of carotenoid analogs with varying numbers of conjugated double bonds, denoted as the Ind series, and conducted femtosecond pump-probe spectroscopy on these molecules in both acetone and n-hexane.
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