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A conserved element in the first intron of has a lineage specific, TCR signal-responsive, canonical enhancer function that matches the timing of cell surface CD4 upregulation required to prevent lineage choice error.
Front Immunol
January 2025
Integrative Immunobiology Department, Duke University, Durham, NC, United States.
Introduction: The regulation of expression during T-cell development and immune responses is essential for proper lineage commitment and function in the periphery. However, the mechanisms of genetic and epigenetic regulation are complex, and their interplay not entirely understood. Previously, we demonstrated the need for CD4 upregulation during positive selection to ensure faithful commitment of MHC-II-restricted T cells to the CD4 lineage.
View Article and Find Full Text PDFManagement of Anal Fistula with Crohn's Disease.
J Anus Rectum Colon
January 2025
Inflammatory Bowel Disease Center, Coloproctology Center Takano Hospital, Kumamoto, Japan.
Crohn's disease (CD) causes gastrointestinal symptoms (i.e., diarrhea and abdominal pain), systemic symptoms (i.
View Article and Find Full Text PDFEffects of Diverting Stoma Creation in Minimally Invasive Surgery for Rectal Cancer.
J Anus Rectum Colon
January 2025
Department of Coloproctological Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Objectives: In rectal cancer surgery, a diverting stoma (DS) is used to prevent severe anastomotic leakage (AL), peritonitis, reoperation, and longer hospitalization. DS creation has increased in the last few decades, without establishment of clear criteria for construction of a DS. Therefore, the goal of the study was to investigate the validity of DS construction based on risk factors for AL, as an approach to reduce the number of stoma creations.
View Article and Find Full Text PDFC-terminal amides mark proteins for degradation via SCF-FBXO31.
Nature
January 2025
Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, Zurich, Switzerland.
During normal cellular homeostasis, unfolded and mislocalized proteins are recognized and removed, preventing the build-up of toxic byproducts. When protein homeostasis is perturbed during ageing, neurodegeneration or cellular stress, proteins can accumulate several forms of chemical damage through reactive metabolites. Such modifications have been proposed to trigger the selective removal of chemically marked proteins; however, identifying modifications that are sufficient to induce protein degradation has remained challenging.
View Article and Find Full Text PDFAssessing Endodontic Treatment Feasibility for Cracked Teeth using Quantitative Light-induced Fluorescence: A Retrospective Clinical Study.
J Endod
January 2025
Department of Conservative Dentistry and Oral Science Research Center, Gangnam Severance Hospital, Yonsei University College of Dentistry, 211 Eonjuro, Gangnamgu, Seoul 06273, Korea. Electronic address:
Introduction: Cracked teeth present diagnostic and treatment challenges due to their complex etiology and uncertain prognoses. This study evaluated the potential of Quantitative Light-induced Fluorescence (QLF) technology for diagnosing cracked teeth and its utility in predicting the need for root canal treatment (RCT).
Methods: A total of 207 cracked teeth from 149 patients diagnosed between April 2019 and April 2023 were analyzed.
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