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Natriuretic peptides and salt sensitivity: endocrine cardiorenal integration in heart failure.
Congest Heart Fail
April 2002
SUNY Upstate Medical University and Veterans Affairs Hospital, Syracuse, NY 13210, USA.
Mammalian hearts contain a family of peptides with potent natriuretic, diuretic, and vasorelaxant actions. In addition to atrial natruretic peptide (ANP) and brain natriuretic peptide, recent studies in humans and animals have suggested that the N-terminal ANP prohormone fragment 31-67 may represent another adaptive mechanism to achieve body fluid homeostasis. Furthermore, these investigations have also suggested that via different mechanisms of action on target organisms, the C-terminal hormone ANP 99-126 and pro-ANP 31-67 may coordinate and contribute to the regulation of hemodynamic and renal function in pathophysiologic situations, such as heart failure.
View Article and Find Full Text PDFDiastolic Heart Failure.
Curr Treat Options Cardiovasc Med
October 2000
Division of Cardiology, Department of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 816, PO Box 250625, Charleston, SC 29425-5799, USA.
The diagnosis of diastolic heart failure (DHF) can be made when a patient has both symptoms and signs on physical exam of congestive heart failure (CHF), and normal left ventricular volume and ejection fraction. Documentation of abnormal diastolic function is confirmatory but not mandatory. Diastolic heart failure is a frequent cause of CHF (prevalence is 35% to 50%) and has a significant effect on mortality (5-year mortality rate is 25% to 35%) and morbidity (1-year readmission rate is 50%).
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