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Liquid biopsy technologies: innovations and future directions in breast cancer biomarker detection.
Biomed Microdevices
January 2025
Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, 25 Taiping Street, Luzhou, 646000, Sichuan, People's Republic of China.
Globally, breast cancer is the most frequent type of cancer, and its early diagnosis and screening can significantly improve the probability of survival and quality of life of those affected. Liquid biopsy-based targets such as circulating tumor cells, circulating tumor DNA, and exosomes have been instrumental in the early discovery of cancer, and have been found to be effective in stage therapy, recurrence monitoring, and drug selection. Biosensors based on these target related biomarkers convert the tested substances into quantifiable signals such as electrical and optical signals through signal transduction, which has the advantages of high sensitivity, simple operation, and low invasiveness.
View Article and Find Full Text PDFNovel euthanasia technique for zebrafish using electric shock in standard group housing aquaria.
Sci Rep
January 2025
Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences, Gothenburg, Sweden.
Zebrafish are widely used in research, accounting for approximately 50% of all laboratory fish across Europe. Due to their rapid reproduction and aging, effective and practical euthanasia methods are necessary for managing large stocks. This study investigated whether adult zebrafish can be euthanised by delivering an electrical current directly via the water in their housing aquaria.
View Article and Find Full Text PDFA method of coating life prediction based on high temperature thermal shock life test and three-dimensional heat transfer analysis.
Sci Rep
January 2025
School of Instrumental Science and Engineering, Harbin Institute of Technology, 150001, Harbin, People's Republic of China.
In this study, a method for predicting the thermal shock life of coatings is proposed, and a model for predicting the thermal shock life of coatings based on high temperature thermal shock life test and three-dimensional heat transfer analysis is established. Firstly, the thermal shock life of coatings at different cooling and heating cycle temperatures is obtained through a designed thermal shock life testing device for silicide coatings at a wide-temperature range from 500℃ to 3000℃. Secondly, the actual thickness of the coating and the continuous oxidation in the thermal shock life test are taken into consideration.
View Article and Find Full Text PDFMagmatic evolution of the Kikai caldera revealed by zircon triple dating and its chemistry.
Sci Rep
January 2025
Central Research Institute of Electric Power Industry, Chiba, 270-1194, Japan.
Reconstructing the volcanic history of the Kikai caldera, a large active volcano that produced a ~ 160 km eruption at 7.3 ka off the southern coast of Kyushu Island (southwest Japan), is crucial to assess potential future volcanic hazards at both regional and global scales. However, revealing its volcanic history before the 7.
View Article and Find Full Text PDFStudy on the mechanics and self-sensing properties of ultrahigh-performance shotcrete containing waste glass aggregates.
Sci Rep
January 2025
Research Center of Traffic Disaster Prevention and Mitigation, Jilin Jianzhu University, Jilin Jianzhu University, Xincheng Street, Changchun, 130118, Jilin, China.
To promote the recycling of waste glass and satisfy the demands of environmental sustainability for ultrahigh performance concrete (UHPC), in this study, glass sand was employed to partially or entirely replace machine-made sand, and steel fibres were incorporated to fabricate ultrahigh performance shotcrete (UHPS). The effects of glass sand and steel fibres on the mechanical and electrical properties of composite materials were analysed in this study. Furthermore, alkali‒silica reaction (ASR) tests and microstructural analyses were conducted.
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