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Colored floaters as a manifestation of digoxin toxicity.
Am J Ophthalmol Case Rep
June 2018
Department of Ophthalmology, Columbia University Medical Center, New York, N.Y., United States.
Purpose: Since its report in one patient more than 70 years ago, digitalis-induced colored muscae volitantes have not surfaced again in the literature. We report here a case of digoxin induced colored floaters.
Observations: An 89-year-old man on 0.
The effects of the purinergic system on digitalis-induced epileptiform activity.
J Basic Clin Physiol Pharmacol
October 1996
Department of Pharmacology, Faculty of Medicine, University of Ondokuz Mayis, Samsun, Turkey.
It has been suggested that endogenous chemical substances, such as adenosine, released during a seizure attack, may act as anticonvulsants in vivo. We have investigated electrophysiologically the effects of purinoceptor agonists and antagonists on the epileptiform activity induced by intracortical digitalis in anesthetized rats. Intracortical injections of 1, 2, or 4 micrograms digitalis (desacetyl lanatocid C) caused an epileptiform electrocorticogram (ECoG).
View Article and Find Full Text PDFMyocardial energetics during ventricular fibrillation investigated by magnetization transfer nuclear magnetic resonance spectroscopy.
Circ Res
November 1992
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Ventricular fibrillation (VF) is known to produce alterations in myocardial energetics, but the mechanism of these changes remains unclear. To investigate energy metabolism during VF, phosphorus nuclear magnetic resonance spectroscopy and magnetization transfer were applied to isolated perfused ferret hearts. VF was induced either by perfusion with digitalis (strophanthidin, 30 microM) or by high-frequency electrical stimulation.
View Article and Find Full Text PDFThe response to overdrive pacing of triggered atrial and ventricular arrhythmias in the canine heart.
Circulation
May 1988
Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Although triggered activity has been identified in isolated atrial tissue with the use of cellular electrophysiologic techniques, there has been no identification of triggered atrial arrhythmias in situ. Moreover, it is unclear whether triggered rhythms of different causes and sites of origin in the heart exhibit uniform responses to pacing that might aid in their identification. We therefore studied arrhythmias induced by overdrive pacing in three canine preparations, and based the analysis of our results on guidelines derived from microelectrode studies.
View Article and Find Full Text PDFToxic doses of digitalis can induce severe arrhythmias in the sinus node. Since digitalis is known to induce electrical uncoupling in heart tissues, it is possible that the arrhythmias may be mediated by cell-to-cell uncoupling leading to desynchronization of pacemaker cells. We investigated this possibility using intracellular recordings and two different preparations of isolated rabbit sinus node.
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