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Metyrapone single administration, as a possible predictive tool of its dosage and timing in Cushing's syndrome.
Front Endocrinol (Lausanne)
January 2025
Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Hospital, Kobe, Japan.
Metyrapone is commonly used in the initial management of Cushing's syndrome to reduce hypercortisolemia, but its optimal dosage and timing can vary significantly between patients. Currently, there are limited guidelines on adjustment methods for its administration to individual needs. This study aimed to evaluate responsiveness of each patient to metyrapone and identify the patient characteristics associated with the indices of cortisol responsiveness following a low-dose metyrapone.
View Article and Find Full Text PDFMild autonomous cortisol secretion leads to reduced volumetric BMD at lumbar spine in patients with primary aldosteronism.
Front Endocrinol (Lausanne)
December 2024
Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany.
Objectives: Glucocorticoid cosecretion is more common in primary aldosteronism (PA) than previously thought. Chronic subtle cortisol excess in patients with mild autonomous cortisol secretion (MACS) negatively affects bone health. This study aimed to evaluate the impact of MACS on bone density and turnover markers in PA patients.
View Article and Find Full Text PDFCortisol awakening response prompts dynamic reconfiguration of brain networks in emotional and executive functioning.
Proc Natl Acad Sci U S A
December 2024
State Key Laboratory of Cognitive Neuroscience and Learning & International Data Group/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China.
Emotion and cognition involve an intricate crosstalk of neural and endocrine systems that support dynamic reallocation of neural resources and optimal adaptation for upcoming challenges, an active process analogous to allostasis. As a hallmark of human endocrine activity, the cortisol awakening response (CAR) is recognized to play a critical role in proactively modulating emotional and executive functions. Yet, the underlying mechanisms of such proactive effects remain elusive.
View Article and Find Full Text PDFDiagnosis and Management of Adrenocortical Carcinoma with Co-secretion of Cortisol and Aldosterone: A Case Report.
J ASEAN Fed Endocr Soc
December 2024
Department of Internal Medicine, Chong Hua Hospital, Cebu City, Philippines.
Article Synopsis
- * A 44-year-old Filipino woman showed symptoms like abdominal weight gain and fatigue due to excess hormones from a 12-year-old left adrenal incidentaloma, leading to a diagnosis of Cushing's syndrome and primary hyperaldosteronism following lab tests.
- * The patient underwent successful surgery to remove the adrenal mass, which was confirmed to be ACC, and received radiotherapy post-operation; the case highlights the importance of evaluating adrenal masses for potential malignancy.
Early-life challenge enhances cortisol regulation in zebrafish larvae.
Biol Open
December 2024
Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research, Jahnstr. 29, 69120 Heidelberg, Germany.
The hypothalamic-pituitary-adrenal (HPA) axis in mammals and the hypothalamic-pituitary-interrenal (HPI) axis in fish are open systems that adapt to the environment during development. Little is known about how this adaptation begins and regulates early stress responses. We used larval zebrafish to examine the impact of prolonged forced swimming at 5 days post-fertilization (dpf), termed early-life challenge (ELC), on cortisol responses, neuropeptide expression in the nucleus preopticus (NPO), and gene transcript levels.
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