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Copper in the colorectal cancer microenvironment: pioneering a new era of cuproptosis-based therapy.
Front Oncol
January 2025
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Copper, an essential trace element and biochemical cofactor in humans plays a critical role in maintaining health. Recent studies have identified a significant association between copper levels and the progression and metastasis of cancer. Copper is primarily absorbed in the intestinal tract, often leading to an imbalance of copper ions in the body.
View Article and Find Full Text PDFRole of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies.
Front Pharmacol
January 2025
Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Copper is an essential micronutrient involved in various physiological processes in various cell types. Consequently, dysregulation of copper homeostasis-either excessive or deficient-can lead to pathological changes, such as heart failure (HF). Recently, a new type of copper-dependent cell death known as cuproptosis has drawn increasing attention to the impact of copper dyshomeostasis on HF.
View Article and Find Full Text PDFImpact of cuproptosis in gliomas pathogenesis with targeting options.
Chem Biol Interact
January 2025
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. Electronic address:
Gliomas constitute the most prevalent primary central nervous system tumors, often characterized by complex metabolic profile, genomic instability, and aggressiveness, leading to frequent relapse and high mortality rates. Traditional treatments are commonly ineffective because of gliomas increased heterogeneity, invasive characteristics and resistance to chemotherapy. Among several pathways affecting cellular homeostasis, cuproptosis has recently emerged as a novel type of programmed cell death, triggered by accumulation of copper ions.
View Article and Find Full Text PDFEvaluating the tolerance of harmful algal bloom communities to copper.
Environ Pollut
January 2025
School of Fisheries, Aquaculture, and Aquatic Sciences, Auburn University, Auburn, AL. Electronic address:
Harmful algal blooms (HABs) cause severe economic and environmental impacts, including hypoxic events and the production of toxins and off-flavor compounds. Chemical treatments, such as copper sulfate pentahydrate (CuSO·5HO), are often used to mitigate the damaging effects of algal blooms. However, treatment effects are usually short-lived leading to waterbodies requiring repeated CuSO·5HO applications to control persistent algal blooms, particularly in highly eutrophic systems, such as aquaculture ponds or small agricultural impoundments.
View Article and Find Full Text PDFA hyaluronic acid modified copper-based metal-organic framework overcomes multidrug resistance via two-way redox dyshomeostasis under hypoxia.
Int J Biol Macromol
January 2025
College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, PR China. Electronic address:
Multidrug resistance (MDR) has become a major challenge in tumor chemotherapy, primarily associated with the overexpression of P-glycoprotein (P-gp). Inhibiting P-gp expression and function through redox dyshomeostasis has shown great potential for reversing MDR. Here, a nanometer system of copper-based metal-organic framework (HA-CuMOF@DOX) modified with hyaluronic acid (HA) was constructed to overcome MDR via two-way regulation of redox homeostasis under hypoxia.
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