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Recent Advances in Natural Products Derived from Marine Echinoderms and Endophytic Microbes: Chemical Insights and Therapeutic Potential.
Mar Drugs
January 2025
Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China.
Echinoderms, a diverse group of marine invertebrates including starfish, sea urchins, and sea cucumbers, have been recognized as prolific sources of structurally diverse natural products. In the past five years, remarkable progress has been made in the isolation, structural elucidation, and pharmacological assessment of these bioactive compounds. These metabolites, including polysaccharides, triterpenoids, steroids, and peptides, demonstrate potent bioactivities such as anticancer, anti-inflammatory, antiviral, and antimicrobial effects, providing valuable insights and scaffolds for drug discovery.
View Article and Find Full Text PDFTwo previously undescribed triterpenoid saponins from the roots and rhizomes of Maxim.
Front Chem
January 2025
Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Air Force Medical University, Xi'an, China.
Since ancient times, plants have provided humans with important bioactive compounds for the treatment of various diseases. Nine compounds were isolated from the roots and rhizomes of Caulophyllum robustum (a plant in the family Panaxaceae), including two new saponins C. Spanion A and C.
View Article and Find Full Text PDFUnlabelled: One of the principles of prevention and non-drug treatment of liver diseases, including hepatitis of various etiologies, is the normalization of the diet, including the use of daily diet foods with physiologically active ingredients, in particular betulin, which helps to reduce metabolic and oxidative processes within liver cells. The aim of the work was to evaluate the in vivo effect of triterpene alcohol betulin Roth isolated from the bark of birch Betula pendula Roth. added to fat-containing products (for example, mayonnaise) on the biochemical parameters of blood and the morphological structure of the liver of rats with initiated acute toxic hepatitis.
View Article and Find Full Text PDFFive new triterpenoids isolated from mastic: Structural identification and their anti-inflammatory activity.
Fitoterapia
January 2025
Jiangxi Provincial Key Laboratory of Natural and Biomimetic Drugs Research, School of Health, Jiangxi Normal University, Nanchang 330022, China.
Five new oleanane-type triterpenoids were isolated from mastic. Their structures including absolute configurations were determined by extensive spectroscopic methods and single-crystal X-ray crystallographic experiments. Compound 1 is distinguished by its rare furan ring.
View Article and Find Full Text PDFUnlocking the therapeutic mechanism of : a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry.
Front Pharmacol
January 2025
Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.
Herbal medicine are an invaluable reservoir of bioactive compounds, offering immense potential for novel drug development to address a wide range of diseases. Among these, has gained recognition for its historical medicinal applications and substantial therapeutic potential. This review explores the ethnopharmacological significance, phytochemical composition, and pharmacological properties of , with a particular focus on its anticancer activities.
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