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Schisandra sphenanthera extract modulates sweet taste receptor pathway, IRS/PI3K, AMPK/mTOR pathway and endogenous metabolites against T2DM.
Phytomedicine
January 2025
School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China; College of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, PR China; Key Laboratory of Pharmacodynamics and Material Basis of Chinese Medicine, Shaanxi Administration of Traditional Chinese Medicine, Xi'an 712046, PR China; Shaanxi Key Laboratory of Research and Application of"Taibai Qi Yao", Xianyang 712046, PR China. Electronic address:
Article Synopsis
- Schisandra sphenanthera, a fruit used in traditional medicine, is reported to have beneficial effects on diabetes mellitus (DM) by helping with symptoms like prolonged cough and thirst and may aid in diabetes prevention and control.
- The research aims to uncover how Schisandra Sphenanthera (SDP) works against type 2 diabetes mellitus (T2DM) through various scientific methods like biochemical analysis and metabolite assays.
- Findings reveal that SDP can lower blood glucose levels, improve metabolic functions, and activate specific signaling pathways, ultimately leading to therapeutic effects on T2DM and restoring damage in organs like the liver and pancreas.
Reninoma: an unusual cause of growth failure.
J Pediatr Endocrinol Metab
January 2025
Department of Endocrinology and Diabetes, Max Super Speciality Hospital, Saket, Delhi, India.
Objectives: Growth failure can result from various underlying causes, necessitating a thorough evaluation. Reninoma, a rare renin-secreting tumor, is an uncommon cause of hypertension, especially in paediatric patients, and has not been associated with growth failure until now.
Case Presentation: An 11-year-old girl presented with complaints of poor height gain, headaches, increased thirst, and vomiting.
High-fat diet stimulated butyric acid metabolism dysbiosis, altered microbiota, and aggravated inflammatory response in collagen-induced arthritis rats.
Nutr Metab (Lond)
November 2024
Department of Traditional Chinese Medicine, The First Hospital of China Medical University, Shenyang, 110001, China.
Article Synopsis
- Research indicates a link between obesity and rheumatoid arthritis (RA), particularly focusing on how high fat diets (HFD) may impact collagen-induced arthritis (CIA) in rats through gut microbiota and metabolomics.
- The study involved categorizing rats into four groups—normal, CIA model, HFD, and HFD + CIA—and measuring various factors like arthritis severity, weight, lipid levels, and inflammation.
- Findings revealed that HFD significantly increased arthritis severity and altered gut microbiota, specifically reducing beneficial bacteria and butyric acid levels, which are associated with inflammation and joint damage in CIA rats.*
The application of QCT in the prognostic assessment of mCRC undergoing first-line treatment based on bevacizumab.
Future Oncol
December 2024
Gastrointestinal Oncology Department, The First Affiliated Hospital of USTC West District, Hefei, Anhui, China.
Background: Bevacizumab induces muscle atrophy by changing the gene expression level of muscle tissue. Quantitative computed tomography (QCT) enables precise measurement of various body compositions, including muscle area.
Materials & Methods: A total of 102 patients with metastatic colorectal cancer (mCRC) undergoing first-line chemotherapy based on bevacizumab were enrolled at thirst Affiliated Hospital of the University of Science and Technology of China.
Bifocal intracranial germ cell tumor: A diagnostic and therapeutic dilemma for radiation oncologists.
J Cancer Res Ther
July 2024
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
An eight-year-old child presenting with increased thirst, raised intracranial tension and visual deterioration was diagnosed with synchronous suprasellar and pineal lesions, for which she underwent partial resection of the suprasellar lesion. Histopathological examination suggested pure germinoma. Tumor marker evaluation showed significantly raised levels of beta human chorionic gonadotropin (βHCG), favoring a non-germinoma germ cell tumor (NGGCT), leading to a diagnostic dilemma as the histology and βHCG levels were contradictory.
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