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Sphingoid Base Diversity.
Atherosclerosis
December 2024
Institute for Clinical Chemistry, University Hospital and University Zurich, 8091, Zürich, Switzerland. Electronic address:
Sphingolipids (SL) are crucial components of cellular membranes and play pivotal roles in various biological processes, including cell growth, differentiation, apoptosis, and stress responses. All SL contain a sphingoid base (SPB) backbone which is the shared and class-defining element. SPBs are heterogeneous in length and structure.
View Article and Find Full Text PDFThe Influence of Diet and Obesity in Lynch Syndrome: What Do We Know So Far.
Nutrients
December 2024
Laboratório Associado, Escola Superior de Biotecnologia, Centro de Biotecnologia e Química Fina, Universidade Católica Portuguesa, CBQF, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Of all new cases of colorectal cancer, Lynch syndrome (LS) accounts for approximately 3%. This syndrome is the most common hereditary cancer syndrome and is caused by pathogenic variants in the genes responsible for DNA mismatch repair. Although the relationship between colorectal cancer risk and diet is well established, little is known regarding the influence of diet and nutritional characteristics on LS's clinical evolution.
View Article and Find Full Text PDFBeyond Skin Deep: Patient Insights Into Cosmetic Procedures and Their Risks in Madinah, Saudi Arabia.
Cureus
November 2024
Department of Community Medicine, Al-Rayan National College of Medicine, Madinah, SAU.
Article Synopsis
- The demand for cosmetic procedures has surged, driven by people's desire for self-improvement, but many are unaware of the risks involved.
- A study in the Madinah community surveyed 82 individuals, mainly young Saudi adults, to understand their awareness of cosmetic procedures and associated complications.
- Although most participants recognized the existence of risks, a significant portion lacked detailed knowledge about specific complications, indicating the need for better education on the topic.
Minimal encephalopathy in hereditary hemorrhagic telangiectasia patients with portosystemic vascular malformations.
Orphanet J Rare Dis
December 2024
HHT Unit. Hospital Universitari Bellvitge, C/Feixa Llarga S/N. L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
Background: Hereditary hemorrhagic telangiectasia (HHT) is characterized by telangiectasia and larger vascular malformations. Liver malformations are the most frequent visceral involvement including the presence of portosystemic malformations (PSM) that can cause hepatic encephalopathy. Minimal hepatic encephalopathy (mHE) is characterized by alterations of brain function in neuropsychological or neurophysiological tests and decreases quality of life.
View Article and Find Full Text PDFClinical and biochemical features of atherogenic hyperlipidemias with different genetic basis: A comprehensive comparative study.
PLoS One
December 2024
Department of Fundamental and Applied Aspects of Obesity, National Medical Research Center for Therapy and Preventive Medicine of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Patients with genetically-based hyperlipidemias exhibit a wide phenotypic variability. Investigation of clinical and biochemical features is important for identifying genetically-based hyperlipidemias, determining disease prognosis, and initiating timely treatment. We analyzed genetic data from 3374 samples and compared clinical data, lipid levels (low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, triglycerides, and lipoprotein (a)), frequency, age at onset of coronary heart disease (CHD), and the severity of carotid and femoral atherosclerosis (plaque number, maximum stenosis, total stenosis, maximum plaque height, and plaque score) among patients with familial hypercholesterolemia (FH), familial dysbetalipoproteinemia (FD), polygenic hypercholesterolemia (HCL), severe HCL, and those without lipid disorders (n = 324).
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