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Methionine Sulfoximine as a Tool for Studying Temporal Lobe Epilepsy: Initiator, Developer, Attenuator.
Neurochem Res
January 2025
Department of Pathophysiology, Medical University of Lublin, 20-090, Lublin, Poland.
Methionine sulfoximine (MSO) is a compound originally discovered as a byproduct of agene-based milled flour maturation. MSO irreversibly inhibits the astrocytic enzyme glutamine synthase (GS) but also interferes with the transport of glutamine (Gln) and of glutamate (Glu), and γ-aminobutyric acid (GABA) synthesized within the Glu/Gln-GABA cycle, in this way dysregulating neurotransmission balance in favor of excitation. No wonder that intraperitoneal administration of MSO has long been known to induce behavioral and/or electrographic seizures.
View Article and Find Full Text PDFThe Role of GSK3β Signaling Mediated Lysosomal Biosynthesis Dysregulation in Fluoride-Induced Neurological Impairment.
Food Chem Toxicol
January 2025
Department of Environmental Health & Environment and Health Innovation Team, School of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China. Electronic address:
Neurological dysfunction induced by fluoride is still one of major concern worldwide, yet the underlying mechanisms remain elusive. To explore whether fluoride disrupts lysosomal biosynthesis via the GSK3β signaling, leading to neurological damage, both in vivo rat models and in vitro PC12 cell models were conducted. Subsequent findings revealed reduced spatial learning and memory abilities, decreased hippocampal neurons, and disrupted neuronal arrangement in NaF-treated rats.
View Article and Find Full Text PDFMachine Learning Analysis of Glutamate Receptor Activity in Developing Locus Coeruleus Neurons.
Int J Neurosci
January 2025
Department of Mathematics, Payame Noor University, Tehran, Iran.
The developing brain undergoes a remarkable process of synapse production and maturation, particularly in glutamatergic synapses. In this study, we focused on the locus coeruleus (LC) nucleus, a brain region crucial for cognitive functions, to investigate the developmental changes in glutamatergic synaptic connections. Using the whole-cell patch clamp method, we recorded evoked excitatory postsynaptic currents (eEPSCs) from LC neurons in rats at ages 7, 14, and 21 days.
View Article and Find Full Text PDFExploring the Mechanism of Acupuncture in Improving Ovarian Function in Rats with Poor Ovarian Response Using High-Throughput Sequencing.
Comb Chem High Throughput Screen
January 2025
Hospital of Chengdu University of Traditional Chinese Medicine, No. 39 Shierqiao Road, Jinniu District, Chengdu, Sichuan, 610072, P.R. China.
Objective: This study aimed to investigate the possible mechanism through which acupuncture protects ovaries with Poor Ovarian Response (POR) in rats based on microRNA (miRNA).
Methods: Thirty-six SPF SD female non-pregnant rats aged 8 weeks were randomly divided into the blank group, model group, and acupuncture group, with 12 rats in each group. According to the group, the rats were given gavage of Tripterygium wilfordii polyglycosides suspension for 14 days to establish the model of POR, and then the rats were treated with acupuncture for 2 weeks, once a day, for 20 minutes.
Photobiomodulation of alveolar bone healing in rats with low-level laser and light emitting diode therapy.
Lasers Med Sci
January 2025
Centro Universitário do Estado do Pará, Belém, Brazil.
The present study investigates the potential contribution of Photobiomodulation (PBM) to the regeneration of the bone following the extraction of the first mandibular molar in rats. The study evaluates the efficacy of PBM, using both Low-Level Laser Therapy (LLLT) and Light-Emitting Diode Therapy (LEDT), as promotors of osteoblastic activity and the formation of new bone. Study design, setting, and sample: 45 male Wistar rats were divided randomly into three groups of 15 individuals - (i) control group (left lower molar removed only), (ii) the LLL group (molar removed, followed by LLLT), and (iii) the LED group (molar removed, followed by LEDT).
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