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Old wine in new bottles: Advanced drug delivery systems for disulfiram-based cancer therapy.
J Control Release
March 2020
Department of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA. Electronic address:
Disulfiram (DSF) is an FDA-approved drug that has been repurposed for cancer treatment. It showed excellent anticancer efficacy in combination with copper ions (Cu). Several active clinical trials testing the anticancer efficacy of DSF against various cancers are underway.
View Article and Find Full Text PDFMental retardation in Down syndrome: Two ways to treat.
Med Hypotheses
October 2019
Biochemistry and Molecular Biology, Paris-Descartes University, 26 rue de Chartres, 92200 Neuilly, France. Electronic address:
Mental retardation is a progressive condition in Down syndrome: intelligence starts to decline linearly within the first year. This phenomenon could be related to the overproduction of a toxic compound, hydrogen sulfide. Indeed, a gene located on chromosome 21 controls the production of cystathionine-β-synthase, an enzyme involved in hydrogen sulfide production in the central nervous system.
View Article and Find Full Text PDF[Acute and reversible myoclonic encephalopathy, extrapyramidal syndrome, polyneuropathy caused by chronic disulfiram poisoning].
Rev Neurol (Paris)
November 1995
Service de Neurologie, CHU Lille.
This 44-year woman was admitted for weight loss and global intellectual slowing. She had mild chronic alcoholic neuropathy. She was discontinued alcoholic consumption for 6 months and was given disulfiram (1.
View Article and Find Full Text PDFWe report the case of a severely malformed and retarded girl whose previously alcoholic mother had taken disulfiram early during the pregnancy, but denied having taken alcohol. The child quite closely resembled the clinical picture of the fetal alcohol syndrome.
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