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Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells.
Cell Metab
January 2025
Henan Academy of Sciences, Zhengzhou 450000, China; Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:
Cellular senescence, a hallmark of aging, involves a stable exit from the cell cycle. Senescent cells (SnCs) are closely associated with aging and aging-related disorders, making them potential targets for anti-aging interventions. In this study, we demonstrated that human embryonic stem cell-derived exosomes (hESC-Exos) reversed senescence by restoring the proliferative capacity of SnCs in vitro.
View Article and Find Full Text PDFThymol inhibits ergosterol biosynthesis in Nakaseomyces glabratus, but differently from azole antifungals.
J Mycol Med
December 2024
Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran; Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:
Introduction: Nakaseomyces glabratus is considered a high priority of attention according to WHO, and also is an important yeast species due to its high rate of intrinsic/acquired resistance against fluconazole. This study aimed at the possible mechanisms of action of thymol, as the promising new antifungal agent, in N. glabratus.
View Article and Find Full Text PDFPCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal.
Tissue Cell
January 2025
Anesthesia Surgery Center, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region 830000, China.
Background: Postoperative cognitive dysfunction (POCD) is a postoperative complication that can be induced by anaesthesia. PCSK9 has been shown to have a role in neuronal development and apoptosis. However, PCSK9 has not been studied in sevoflurane-induced POCD-related disorders.
View Article and Find Full Text PDFInsights Into the Local Heating Effects in Triple-Cation Mixed-Halide Perovskite Cells: Charge Dynamics, Coherent Phonons, Anion Segregation.
Small
January 2025
Faculty of Physics and Astronomy, Adam Mickiewicz University, Poznan, 61-614, Poland.
The behavior of triple-cation mixed halide perovskite solar cells (PSCs) under ultrashort laser pulse irradiation at varying fluences is investigated, with a focus on local heating effects observed in femtosecond transient absorption (TA) studies. The carrier cooling time constant is found to increase from 230 fs at 2 µJ cm⁻ to 1.3 ps at 2 mJ cm⁻ while the charge population decay accelerates from tens of nanoseconds to the picosecond range within the same fluence range.
View Article and Find Full Text PDFA Case Series With Cysteamine-Isobionicamide Complex: Clues for Skin-Rejuvenating Activity.
J Cosmet Dermatol
January 2025
Scientis SA, Geneva, Switzerland.
Background: Skin aging is inevitable. Wrinkles, skin texture abnormalities, senile hyperpigmentation, loss of skin tone, dryness, atrophy, and telangiectasias represent some of the hallmarks of aged skin. Skin rejuvenation can be addressed by topical therapies, such as topical retinoids and antioxidants or physical modalities with energy-based devices, all providing acceptable outcomes.
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