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Towards assembling functional cyanobacterial β-carboxysomes in Oryza sativa chloroplasts.
Funct Integr Genomics
January 2025
The Energy and Resources Institute, Lodi Road, New Delhi, 110003, India.
The major limiting factor of photosynthesis in C3 plants is the enzyme, rubisco which inadequately distinguishes between carbon dioxide and oxygen. To overcome catalytic deficiencies of Rubisco, cyanobacteria utilize advanced protein microcompartments, called the carboxysomes which envelopes the enzymes, Rubisco and Carbonic Anhydrase (CA). These microcompartments facilitate the diffusion of bicarbonate ions which are converted to CO by CA, following in an increase in carbon flux near Rubisco boosting CO fixation process.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Background: Cardiovascular disease causes vascular dementia and contributes to most clinical dementia. This is embodied in the concept of vascular contributions to cognitive impairment and dementia (VCID). The potent endogenous peptide endothelin-1 (ET1) causes small artery vasoconstriction and fibrosis.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Institute of Human Behaviour and Allied Sciences, Delhi, Delhi, India.
Background: Cognitive Reserve(CR) a concept based on the brain plasticity, is a mechanism that delays or minimizes clinical manifestations of brain changes due to aging. Prospective epidemiologic studies non-demented individuals have shown that education, occupational duration and complexity, and greater lifetime engagement in cognitively stimulating activities are associated with a reduced risk of dementia. We study the cognitive reserve and its neuroimaging correlate.
View Article and Find Full Text PDFBackground: We have previously shown that there are 3 unique behavioral symptom clusters, or groupings of temporally related co-occurring behavioral and psychological symptoms (BPSD) representing how an individual's daily BPSD group together relative to their own typical BPSD manifestation across a 21-day period. To further validate these symptom cluster concepts, we examined whether they are predicted by different environmental triggers.
Method: Family caregivers completed daily diary surveys for 8 consecutive days reporting on the physical, social and care environment in addition to their care recipients different BPSD.
Small molecule APOL1 inhibitors as a precision medicine approach for APOL1-mediated kidney disease.
Nat Commun
January 2025
Vertex Pharmaceuticals Incorporated, Boston, MA, USA.
Chronic kidney disease affects ~10% of people worldwide and there are no disease modifying therapeutics that address the underlying cause of any form of kidney disease. Genome wide association studies have identified the G1 and G2 variants in the apolipoprotein L1 (APOL1) gene as major contributors to a subtype of proteinuric kidney disease now referred to as APOL1-mediated kidney disease (AMKD). We hypothesized that inhibition of APOL1 could have therapeutic potential for this genetically-defined form of kidney disease.
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