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Metal Ion and Antibiotic Co-loaded Nanoparticles for Combating Methicillin-Rresistant -Induced Osteomyelitis.
ACS Nano
January 2025
Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing 400038, China.
Methicillin-resistant (MRSA) causes osteomyelitis (OM), which seriously threatens public health due to its antimicrobial resistance. To increase the sensitivity of antibiotics and eradicate intracellular bacteria, a Zn and vancomycin (Van) codelivered nanotherapeutic (named Man-Zn/Van NPs) was fabricated and characterized via mannose (Man) modification. Man-Zn/Van NPs exhibit significant inhibitory activity against extra- and intracellular MRSA and obviously decrease the minimum inhibitory concentration of Van.
View Article and Find Full Text PDFNanoscale Metal-Organic Frameworks for the Co-Delivery of Cycloxaprid and Pooled siRNAs to Enhance Control Efficacy in .
J Agric Food Chem
January 2025
China-Kenya Joint Laboratory for Ecological Pest Control of Citrus, State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Key Laboratory of Biopesticide and Chemical Biology, MOE, College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
RNA pesticides have emerged as a promising alternative to conventional chemical pesticides due to their high specificity and minimal environmental impact. However, the instability of RNA molecules in the environment and the challenges associated with their effective delivery to target pests limit their broader application. This study addresses these challenges by developing a dual delivery system using chitosan (CS) and Metal-Organic Frameworks (MOFs) to enhance the delivery and efficacy of double-stranded RNA (dsRNA) and cycloxaprid against , a vector of citrus greening disease.
View Article and Find Full Text PDFLess cytotoxic phthalocyanine derivative promotes in vitro wound healing compared to chlorhexidine.
J Appl Biomater Funct Mater
January 2025
Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
The use of adjunct chemical substances in the early postoperative period of periodontal surgical procedures is recommended due to the potential risk of trauma in the operated area. Chlorhexidine digluconate mouthwash is widely used but can cause adverse effects. Phthalocyanine derivatives are being studied as an alternative, demonstrating good antimicrobial activity, especially in the self-activated form, which does not require additional light or chemicals.
View Article and Find Full Text PDFBipyramidal gold nanoparticles-assisted plasmonic photothermal therapy for ocular applications.
J Mater Chem B
January 2025
Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Department of Ophthalmology, Reina Sofia University Hospital and University of Cordoba, 14004 Cordoba, Spain.
Gold nanoparticles (AuNPs) play a key role in the field of nanomedicine due to their fascinating plasmonic properties as well as their great biocompatibility. An intriguing application is the use of plasmonic photothermal therapy (PPTT) mediated by anisotropic AuNPs irradiated with a near-infrared (NIR) laser for treating ocular diseases in ophthalmology. For this purpose, bipyramidal-shaped AuNPs (BipyAu), which were surface-functionalized with three different organic ligands (citrate, polystyrene sulphonate (PSS), and cetyltrimethylammonium bromide (CTAB)), were synthesized.
View Article and Find Full Text PDFTetragonal NaVPOF@rGO nanocomposite as a high-rate cathode for aqueous zinc-ion batteries.
Chem Commun (Camb)
January 2025
School of Materials and Energy, Guangdong University of Technology, Guangzhou 510006, Guangdong, China.
A tetragonal NaVPOF coated with reduced graphene oxide (rGO) manifests an outstanding high-rate capability of 90.6 mA h g at 10C and a stable capacity of 41.9 mA h g after 4000 cycles at 30C owing to the enhanced electronic conductivity and improved Zn diffusion capability from the rGO coating.
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