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Annexin-derived self-assembling peptide nanostructures for alleviation of calcium oxalate -induced renal injury.
Urolithiasis
December 2024
Materials Engineering, Indian Institute of Technology Gandhinagar, Palaj, Gandhinagar, India.
The formation of polycrystalline aggregates in the glomerulus or other components of the urinary system is indisputably the most critical step in the formation of kidney stones and calcium oxalate monohydrate (CaCO·HO) is the most prevalent form. On the other hand, Annexin A1 (ANXA1), a calcium-binding protein, markedly increased on the apical surface of renal cells in CaCO-induced nephrolithiasis. In this regard, we identified the peptide motif responsible for calcium binding and redesigned it into a self-assembling peptide sequence without disturbing its binding selectivity for the CaCO interface.
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- - Coal is being explored as a cost-effective and abundant material for creating hard carbon (HC) anodes in sodium-ion batteries, but the presence of inorganic salts has complicated its effects on the structure of these anodes.
- - Researchers developed a two-step pyrolysis process, including an acid washing step, revealing that salts can help create open pores at lower temperatures while preventing pore closure at higher temperatures.
- - The resulting optimized hard carbon shows impressive performance metrics, such as a reversible capacity of 322.4 mAh/g and high energy density when paired with an NVPOF cathode, showcasing a promising method for scalable production of coal-based HCs.
Changes in Digestive Enzyme Activities during Larval Development of Spotted Seatrout ().
Aquac Nutr
May 2024
Laboratorio de Fisiología en Recursos Acuáticos, División Académica de Ciencias Biológicas, Universidad Juárez Autónoma de Tabasco (UJAT), 0.5 km Carretera Villahermosa-Cárdenas, 86000, Villahermosa, Tabasco, Mexico.
The spotted seatrout ()-an important commercial species-has a high potential for aquaculture in the Gulf of Mexico. To optimize its feeding during larval rearing, this study aims to evaluate the primary gastric (pepsin), intestinal (leucine aminopeptidase and alkaline phosphatase), and pancreatic (alkaline protease, trypsin, chymotrypsin, amylase, and lipase) enzyme activities from hatching to day 30. A multivariate analysis identified three digestive enzyme development stages during the spotted seatrout larval transformation.
View Article and Find Full Text PDFMapping of the Lipid-Binding Regions of the Antifungal Protein NFAP2 by Exploiting Model Membranes.
J Chem Inf Model
August 2024
Institute of Materials and Environmental Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tudósok körútja 2, Budapest, H-1117, Hungary.
Fungal infections with high mortality rates represent an increasing health risk. The antifungal protein 2 (NFAP2) is a small, cysteine-rich, cationic protein exhibiting potent anti- activity. As the underlying mechanism, pore formation has been demonstrated; however, molecular level details on its membrane disruption action are lacking.
View Article and Find Full Text PDFHigh-resolution yeast actin structures indicate the molecular mechanism of actin filament stiffening by cations.
Commun Chem
July 2024
Department of Biological Engineering, Department of Electrical and Computer Engineering, Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA, 93106, USA.
Actin filament assembly and the regulation of its mechanical properties are fundamental processes essential for eukaryotic cell function. Residue E167 in vertebrate actins forms an inter-subunit salt bridge with residue K61 of the adjacent subunit. Saccharomyces cerevisiae actin filaments are more flexible than vertebrate filaments and have an alanine at this position (A167).
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