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Polycystic Ovary Syndrome Accompanied by Hyperandrogenemia or Metabolic Syndrome Triggers Glomerular Podocyte Injury.
Diagnostics (Basel)
October 2024
Department of Anatomy, Histology, Pathology, and Forensic Medicine, Faculty of Medicine, University of Sofia "St. Kliment Ohridski", 1407 Sofia, Bulgaria.
To determine whether the urinary excretion of podocyte degradation products varies according to PCOS phenotype and metabolic syndrome (MetS). The concentrations of podocalyxin (PDX) and nephrin, chronic markers of podocyte damage, and neutrophil gelatinase-associated lipocalin (NGAL), a marker of acute glomerular damage, were analyzed in the morning urine samples of 50 PCOS patients and 50 healthy controls matched by age and BMI. Albuminuria was assessed by calculating the urine albumin-creatinine ratio (uACR).
View Article and Find Full Text PDFSelenium Improves Arsenic-Induced Male Reproductive Dysfunction by Regulating H3K14ac Level.
Biol Trace Elem Res
October 2024
School of Public Health, Lanzhou University, Gansu Province, Lanzhou, People's Republic of China.
Article Synopsis
- * Selenium enhances male reproductive health by improving sperm quality and testosterone levels while reducing arsenic accumulation in the testes.
- * The study identifies that a dose of 1 mg/kg selenium is optimal for counteracting arsenic's harmful effects on male reproductive functions through the H3K14ac pathway.
Capacitation of ram spermatozoa promotes changes in energy metabolism and aquaporin 3 and is affected by individual testosterone variations.
Andrology
September 2024
Departament of Animal Reproduction, National Institute for Agricultural and Food Research and Technology (CSIC), Madrid, Spain.
Background: Recently, the metabolic pathways involved in energy production and the role of aquaglyceroporins in capacitation-associated events have been studied in humans and mice. However, little is known about these in ram spermatozoa.
Objective: The present study investigated bioenergetic and aquaglyceroporin 3 variations during in vitro capacitation of ram spermatozoa.
Mild coronavirus disease 2019: Results of a multicentric prospective study on severe acute respiratory syndrome coronavirus 2 presence in semen fractions and cells and its effects on semen parameters.
Andrology
August 2024
Laboratoire de Virologie, Institut Fédératif de Biologie, CHU de Toulouse, Toulouse, France.
Background: Severe acute respiratory syndrome coronavirus 2, the virus responsible for coronavirus disease 2019, affects multiple organs. The virus enters cells through angiotensin-converting enzyme-2 and host factors present in genital organs, leading to concern over virus shedding in semen and reproductive function.
Objectives: To investigate severe acute respiratory syndrome coronavirus 2 in semen from patients with a mild infection, identify the seminal infected cells, and explore the effect of the infection on sex hormones and semen parameters.
Endocrine-disrupting effects of bisphenol-A, thiamethoxam, and fipronil in hormone-naïve transmen compared to cis-women.
Hormones (Athens)
September 2024
Department of Psychiatry, School of Medicine, Marmara University, Istanbul, Turkey.
Article Synopsis
- - The study explores potential causes of gender dysphoria (GD), specifically investigating the impact of endocrine-disrupting chemicals (EDCs) like bisphenol A (BPA), thiamethoxam, and fipronil on hormone-naïve transmen compared to cis-women.
- - Researchers found that drug-naïve transmen had higher levels of androgens (like testosterone) than cis-women, while thiamethoxam levels were higher in cis-women; BPA and fipronil levels were similar across both groups.
- - The findings suggest that while EDCs may play a role in GD, they are not the sole factor, and the high testosterone levels in trans
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