Elevated doses of the cytostatic cyclophosphamide (Endoxan) given daily for 6 weeks, resulted in a prolonged course of experimental trichophytosis in guinea-pigs. From this phenomenon, it may be concluded that the short self-healing course of this disease is due to a rapid triggering of immunoreactions. The fractionated treatment with cyclophosphamide at defined intervals (50 mg/kg initially and 30 mg/kg at 4-day intervals) did not result in any effect.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Prevalence and Comparison of Superficial-Cutaneous Fungal Infections Before and During the COVID-19 Pandemic in Shiraz, Iran: A Retrospective Study (2018-2021).
Indian J Microbiol
December 2024
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
The use of personal protective equipment such as gloves and masks and protective measures such as repeated contact of hands with water and skin disinfectants are recommended to prevent the spread of Corona virus disease 2019 (COVID-19). However, these hygiene measures may cause skin injury and skin diseases, including superficial-cutaneous-fungal infections (SCFIs). The aim of this study was to determine the prevalence and comparison of SCFIs before and during the COVID-19 pandemic.
View Article and Find Full Text PDFStrategies for genetic manipulation of the halotolerant black yeast : ectopic DNA integration and marker-free CRISPR/Cas9 transformation.
Microbiol Spectr
January 2025
Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, USA.
is a halotolerant black yeast commonly found in hypersaline environments. This yeast is also the causative agent of tinea nigra, a superficial mycosis of the palm of the hand and soles of the feet of humans. In addition to their remarkable halotolerance, this black yeast exhibits an unconventional cell division cycle, alternating between fission and budding cell division.
View Article and Find Full Text PDFChallenging case of and in psoriatic patient treated with bimekizumab: The usefulness of mycological screening before biological therapies.
Med Mycol Case Rep
December 2024
Dermatology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133, Rome, Italy.
Psoriasis is a multifactorial immune-mediated disorder linked to the interleukin (IL)-17 signalling pathway. We present an unusual case of and caused by that developed after starting the IL-17A/F inhibitor bimekizumab. Our case underlines how psoriatic patients, treated with IL-17 inhibitors, should be screened for cutaneous fungal infections before and during treatment, in order to exclude a concomitant infection or the risk of its exacerbation.
View Article and Find Full Text PDFAutomated grading system for quantifying KOH microscopic images in dermatophytosis.
Diagn Microbiol Infect Dis
January 2025
Manipal School of Information Sciences, Manipal Academy of Higher Education, Manipal, 576104, Karnataka, India. Electronic address:
Article Synopsis
- - The study focuses on creating an automated grading system to quantify fungal loads in microscopic images from skin scrapings of patients with dermatophytosis, which is a fungal infection of the skin
- - A U-Net model was used to segment fungal filaments in the images, and expert manual grading was performed since there were no pre-established pixel count thresholds
- - The automated system showed promising results with high accuracy (over 80% for most metrics) and a strong agreement with human grading, indicating it could be an effective and affordable method for assessing fungal loads.
Cold atmospheric plasma as a promising tool in treatment of Trichophyton rubrum-induced skin infection in a guinea pig model of experimental dermatophytosis.
Diagn Microbiol Infect Dis
December 2024
Department of Mycology, Pasteur Institute of Iran, Tehran 1316943551, Iran. Electronic address:
The emergence of high-resistance strains to known antifungal drugs has highlighted the urgency of developing novel therapies for chronic dermatophytosis as a global health problem. An experimental dermatophytosis model in guinea pigs was developed to investigate the in vivo wound healing effects of cold atmospheric plasma (CAP) on T. rubrum skin invasion.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!