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Enantiomer-Dependent Supramolecular Antibacterial Therapy for Drug-Resistant Bacterial Keratitis.
Langmuir
January 2025
National Engineering Research Center of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China.
Bacteria have the potential to exhibit divergent stereochemical preferences for different levels of chiral structures, including from molecule, supramolecule, to nanomicroscale helical structure. Accordingly, the structure-activity relationship between chirality and bactericidal activity remains uncertain. In this study, we seek to understand the multivalent molecular chirality effect of chiral supramolecular polymers on antibacterial activity.
View Article and Find Full Text PDFCarboxy-Amidated AamAP1-Lys has Superior Conformational Flexibility and Accelerated Killing of Gram-Negative Bacteria.
Biochemistry
January 2025
Department of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria 0002, South Africa.
C-terminal amidation of antimicrobial peptides (AMPs) is a frequent minor modification used to improve antibacterial potency, commonly ascribed to increased positive charge, protection from proteases, and a stabilized secondary structure. Although the activity of AMPs is primarily associated with the ability to penetrate bacterial membranes, hitherto the effect of amidation on this interaction has not been understood in detail. Here, we show that amidation of the scorpion-derived membranolytic peptide AamAP1-Lys produces a potent analog with faster bactericidal activity, increased membrane permeabilization, and greater Gram-negative membrane penetration associated with greater conformational flexibility.
View Article and Find Full Text PDFNanoclay-Mediated Crystal-Phase Engineering in Biofunctions to Balance Antibacteriality and Cytotoxicity.
Nano Lett
January 2025
Engineering Research Center of Nano-Geomaterials of Ministry of Education, China University of Geosciences, Wuhan 430074, China.
The crystalline phase of metal oxides is a key determinant of the properties and functions of the nanomaterials. Traditional approaches have focused on replicating bulk-phase structures, with limited exploration of phase diversity due to challenges in controlling the crystal morphology. Here, we introduce a nanoclay-mediated strategy for crystal-phase engineering, using talc to modulate the morphology and phase of manganese oxide (MnOx) nanoparticles.
View Article and Find Full Text PDFSolid-State Precipitation of Silver Nanoparticles Nucleated during Al Anodizing: Mechanism and Antibacterial Properties.
ACS Appl Bio Mater
January 2025
Laboratório de Processos Eletroquímicos e Corrosão-ELETROCORR, Departamento de Metalurgia, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves 9500, 91501-970 Porto Alegre, Brazil.
This study presents an innovative approach to creating antibacterial aluminum surfaces by combining the antibacterial properties of silver nanoparticles (Ag NPs) with the nanoarchitecture of anodized aluminum oxide in one step. An Al-Ag alloy containing 10 wt % Ag was synthesized and anodized in 0.3 M oxalic acid.
View Article and Find Full Text PDFIn-vitro study of hybrid silver nanoparticles with humic acid extracted from cow dung against pathogens.
Heliyon
January 2025
Institute of Metal Research (IMR), Chinese Academy of Science, Wenhua Road, Shenyang, China.
Recently, researchers have used silver nanoparticles (AgNPs) coupled with humic acid (HA) as antimicrobial agents. Herein, AgNPs were prepared and coupled with humic acid for their antimicrobial activities. The as-prepared AgNPs coupled with humic acid (HA) were characterized by an atomic force microscope (AFM), X-ray powder diffraction (XRD), zeta potential, zeta sizer, Fourier-transform infrared (FT-IR) spectroscopy, and UV-VIS spectrophotometer.
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