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An Eco-Friendly and Sensitive Microwave-Aided Spectrofluorophotometric Characterization of Mirabegron-Loaded Nanocarriers by Amalgamation of Design of Experiments and White Analytical Chemistry.
Luminescence
December 2024
Department of Quality Assurance and Pharmaceutics, Maliba Pharmacy College, Surat, Gujarat, India.
Article Synopsis
- * A new microwave-assisted spectrofluorimetric technique was developed using environmentally friendly solvents and a fluorescent probe to reduce organic waste, meeting industry validation standards.
- * The proposed method was found to be user-friendly, cost-effective, and environmentally sustainable, effectively minimizing ecological impact while providing reliable drug analysis.
Microwave-derivatized enhanced-spectrofluorophotometric characterization of nateglinide-loaded solid dispersion adsorbate and greenness profile assessment of method.
Anal Sci
December 2024
Department of Quality Assurance, Maliba Pharmacy College, Maliba Campus, Bardoli-Mahuva Road, Tarsadi, Mahuva, Surat, 394 350, Gujarat, India.
Nateglinide is an oral meglitinide that treats diabetes. Nateglinide was determined in several commercial formulations using chromatographic and spectrophotometric methods in published research. Quality-by-design approach was applied to develop the in-house nateglinide-loaded Solid Dispersion Adsorbate (SDA) for improving bioavailability and solubility.
View Article and Find Full Text PDFWhiteness, redness, blueness and greenness profile assessment and design of experiments approach to microwave-aided sensitive and green spectrofluorophotometric determination of baclofen.
Luminescence
October 2024
Department of Quality Assurance, Maliba Pharmacy College, Maliba Campus, Bardoli-Mahuva Road, Tarsadi, Mahuva, Surat, Gujarat, India.
As a gamma amino butyric acid-ergic agonist, Baclofen is often prescribed to adults and children for the treatment of severe spasticity that originates in the brain or spinal cord. Even after reviewing the literature extensively, no one has documented a method for estimating baclofen using microwave-assisted stability-indicating spectrofluorimetric techniques, despite the abundance of options for baclofen stability, assay, and bioanalysis. Organic solvents, which are typically necessary for current procedures but may be costly and toxic, have a severe effect on aquatic life and the environment.
View Article and Find Full Text PDF[Deletion polymorphism of GSTT1 gene and lipid peroxidation hyperactivation in menopausal insomnia].
Zh Nevrol Psikhiatr Im S S Korsakova
April 2021
Scientific Centre for Family Health and Human Reproduction Problems, Irkutsk, Russia.
Objective: A comparative analysis of the parameters of lipid peroxidation - antioxidant defense system in menopausal women with- and without insomnia, depending on the polymorphism.
Material And Methods: The study included 181 menopausal Caucasian women (ethnic group - Russians), who according to the results of the clinical-anamnestic examinations were divided into insomnia group (=120, age 53.68±4.
Compatibility of phospholipid liposomal spray with silicone hydrogel contact lens wear.
Cont Lens Anterior Eye
February 2017
Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand. Electronic address:
Purpose: To assess the effects of two weeks of regular phospholipid liposomal spray application on lipid layer grade, tear film stability, subjective comfort, visual acuity, and lipid deposition in silicone hydrogel contact lens wearers.
Methods: Thirty-one existing contact lens wearers were enrolled and fitted with two week planned replacement silicone hydrogel contact lenses (Acuvue Oasys) in a prospective, randomized, paired-eye, investigator-masked trial. A phospholipid liposomal spray (Tears Again) was applied to one eye (randomized) four times daily for two weeks.
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