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[Atypical defibrination syndromes and acute leukemias with a t(9,22) translocation, apropos of 2 cases].
Pathol Biol (Paris)
April 2001
Service d'hématologie, hôpital Aziza Othmana, place du Gouvernement, La Kasbah, 1007 Tunis, Tunisie.
We report two cases of atypical defibrination syndromes in patients with respectively acute monoblastic leukemia (chronic myeloid leukemia initially) and acute lymphoblastic leukemia. Hemostasis studies show low fibrinogen level, elevated D-dimers, decreased alpha 2 antiplasmin and factor V, normal antithrombin III values. Plasminogen is below the normal range in one patient.
View Article and Find Full Text PDFHaemodialysis without anticoagulant: haemostasis parameters, fibrinogen kinetic, and dialysis efficiency.
Nephrol Dial Transplant
January 1997
Nephrology Division, Hospital das Clínicas, University of São Paulo School of Medicine, Brazil.
Background: Haemodialysis without anticoagulant is an alternative to systemic anticoagulation of patients at high risk of bleeding. However, reports have suggested that heparin-free haemodialysis might results in blood defibrination, and fibrin deposition in dialytic membrane with possible reduction in dialyser efficiency.
Methods: Haemostasis parameters, fibrin-fibrinogen kinetic assessed by 125I-fibrinogen (125I-F) turnover and 125I-fibrinogen deposition within the dialyser membranes, and dialytic efficiency were studied in 10 stable chronic uraemic patients.
Effects of enzymatic blood defibrination in subcortical arteriosclerotic encephalopathy.
J Neurol Neurosurg Psychiatry
August 1988
Department of Neurology, University Hospital of the RWTH Aachen, Federal Republic of Germany.
Plasma hyperviscosity is a striking abnormality in patients suffering from subcortical arteriosclerotic encephalopathy (SAE) and is thought to perpetuate the chronic ischaemic demyelinating process of the periventricular white matter. Ancrod, a defibrinating enzyme, was given to 10 patients with SAE in an attempt to reduce plasma fibrinogen, which would thus normalise hyperviscosity. This was paralleled by a significant improvement of the initially abnormal retinal arteriovenous passage time, as well as a significant augmentation of the CO2-induced cerebral vasomotor response.
View Article and Find Full Text PDFTraditionally, blood rheology tests have been used in diagnosis and monitoring of infection, rheumatic diseases and malignancy, and are still of clinical value in these conditions. In the last twenty years, clinical and epidemiological studies have shown that the haematological determinants of blood flow resistance (haematocrit, fibrinogen, white cell count and altered red and white cell rigidity) are also associated with nutritional, metabolic, endocrine and vascular disorders. Decreased red cell deformability may contribute to reduced red cell survival and anaemia in burns, malaria, liver disease and kidney failure.
View Article and Find Full Text PDFKnown variously as disseminated intravascular coagulation, defibrination consumption coagulopathy or, more simply, as defibrination, disseminated intravascular coagulation is a serious epiphenomenon that occurs most often as a complicating factor of an underlying disease process. Although frequently triggered by underlying disease such as infection or tumor, if not recognized and treated appropriately, disseminated intravascular coagulation alone may lead to the patient's death as a result of hemorrhage or thrombosis, or both, of vital organs. Frequently, it may only manifest itself as an abnormality of coagulation tests, causing no immediate problem for the patient, and potentially normalizing when the inciting cause is appropriately managed.
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